Intermolecular Radical C-C Bond Formation: Synthesis of a Novel Dinucleoside Linker for Non-anionic Antisense Oligonucleosides

Article abstract of DOI:10.1016/S0040-4039(00)79047-2

An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction.The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides.Key Words: antisense oligonucleotides, nonionic backbone, intermolecular radical reaction