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140712-80-7

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140712-80-7 Usage

General Description

N4-BENZOYL-3'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE is a chemical compound that is composed of a benzoic acid group attached to the nitrogen atom at position 4, and a 2'-deoxycytidine molecule attached to a 3'-O-(4,4'-dimethoxytrityl) group. N4-BENZOYL-3'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE is used in organic synthesis and nucleic acid research as a building block for the production of modified nucleosides and nucleotides. Its specific structure and functional groups make it useful in the development of nucleic acid analogs and can be utilized to study the biological processes involving cytidine nucleosides. The compound can also be used in the preparation of oligonucleotides for therapeutic and diagnostic purposes in molecular biology and medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 140712-80-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,7,1 and 2 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 140712-80:
(8*1)+(7*4)+(6*0)+(5*7)+(4*1)+(3*2)+(2*8)+(1*0)=97
97 % 10 = 7
So 140712-80-7 is a valid CAS Registry Number.

140712-80-7 Well-known Company Product Price

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  • Alfa Aesar

  • (H52799)  N-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine, 97%   

  • 140712-80-7

  • 250mg

  • 634.0CNY

  • Detail
  • Alfa Aesar

  • (H52799)  N-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine, 97%   

  • 140712-80-7

  • 1g

  • 1901.0CNY

  • Detail
  • Alfa Aesar

  • (H52799)  N-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine, 97%   

  • 140712-80-7

  • 5g

  • 7605.0CNY

  • Detail

140712-80-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name N4-BENZOYL-3'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE

1.2 Other means of identification

Product number -
Other names N4-benzoyl-3'-O-dimethoxytrityl-2'-deoxycytidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:140712-80-7 SDS

140712-80-7Relevant articles and documents

Novel chemoenzymatic protocol for the synthesis of 3′-O- dimethoxytrityl-2′-deoxynucleoside derivatives as building blocks for oligonucleotide synthesis

Diaz-Rodriguez, Alba,Fernandez, Susana,Sanghvi, Yogesh S.,Ferrero, Miguel,Gotor, Vicente

, p. 581 - 587 (2006)

An easy, efficient, and scalable chemoenzymatic strategy for the synthesis of 3′-O-dimethoxytrityl-2′-deoxynucleosides has been developed. A key feature of this approach is the regioselective synthesis of 5′-O-levulinyl-2′-deoxynucleosides through enzymatic acylation in the presence of Candida antarctica lipase B. In addition, it was observed that the deblocking of levulinyl group from the 5′-position is perfectly compatible with conventional base protecting groups. To demonstrate the scalability of this method, 3′-O-dimethoxytritylthymidine (4a) was synthesized on 25-g scale. These monomers (4a-d) are useful building blocks for the synthesis of oligonucleotides.

Method for purifying protected 2'-deoxycytidines and hydrated crystals thereof

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Page 4, (2008/06/13)

A protected 2′-deoxycytidine is purified by precipitating the protected 2′-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the protected 2′-deoxycytidine and water, and by recovering the protected 2′-deoxycytidine: wherein R1 represents a 4-methoxytrityl, 4,4′-dimethoxytrityl, or triphenylmethyl group; and B1 represents a cytosine group having a protected amino group. The compound represented by general formula (3) is, in particular, a protected 2′-deoxycytidine represented by formula (4): The 2′-deoxycytidine is used as a raw material for antisense DNA.

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