1408054-69-2

Basic information

• Product Name: C₂₁H₂₆ClN₅O₃
• CAS NO: 1408054-69-2
• Molecular Weight: 431.922
• Mol File: 1408054-69-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₆ClN₅O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₆ClN₅O₃(1408054-69-2)
• EPA Substance Registry System: C₂₁H₂₆ClN₅O₃(1408054-69-2)

Safety Data

• Hazardous Substances Data: 1408054-69-2(Hazardous Substances Data)

Upstream product

• 21427-61-2 5-chloro-3-nitropyridin-2-ol 
• 1443995-76-3 C₂₆H₃₄ClN₅O₅ 
• 4214-79-3 5-chloro-2-pyridinol 
• 1443995-24-1 C₁₁H₁₃ClN₄O₃ 
• 1443995-22-9 C₆H₅ClN₄O 
• 1443995-21-8 C₆H₃ClN₄O₃ 
• 22353-46-4 5-chloro-2-hydrazino-3-nitropyridine 
• 21427-62-3 2,5-dichloro-3-nitropyridine 

Relevant articles and documents

Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors

New potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives, were designed by modeling, synthesized and evaluated in vitro. Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 μM). Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration.