22353-46-4

Basic information

• Product Name: (5-Chloro-3-nitro-pyridin-2-yl)-hydrazine
• Synonyms: (5-Chloro-3-nitro-pyridin-2-yl)-hydrazine
• CAS NO: 22353-46-4
• Molecular Formula: C5H5ClN4O2
• Molecular Weight: 188.5718
• Mol File: 22353-46-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 134-135 °C
• Boiling Point: 239.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.78±0.1 g/cm3(Predicted)
• PKA: 4.00±0.70(Predicted)
• CAS DataBase Reference: (5-Chloro-3-nitro-pyridin-2-yl)-hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (5-Chloro-3-nitro-pyridin-2-yl)-hydrazine(22353-46-4)
• EPA Substance Registry System: (5-Chloro-3-nitro-pyridin-2-yl)-hydrazine(22353-46-4)

Safety Data

• Hazardous Substances Data: 22353-46-4(Hazardous Substances Data)

Usage

General Description

(5-Chloro-3-nitro-pyridin-2-yl)-hydrazine is a chemical compound that consists of a pyridine ring with a chlorine atom at position 5 and a nitro group at position 3. It also contains a hydrazine functional group attached to the pyridine ring. (5-Chloro-3-nitro-pyridin-2-yl)-hydrazine is often used as a building block in the synthesis of various organic compounds and pharmaceuticals. It is known for its ability to participate in various organic reactions including nucleophilic substitution, condensation, and reduction reactions. Additionally, it has been studied for its potential as a pesticide and antimicrobial agent due to its structural properties.

Upstream product

• 21427-61-2 5-chloro-3-nitropyridin-2-ol 
• 4214-79-3 5-chloro-2-pyridinol 
• 21427-62-3 2,5-dichloro-3-nitropyridine 

Downstream Products

• 1443995-75-2 C₂₁H₂₅ClN₄O₄ 
• 1443995-76-3 C₂₆H₃₄ClN₅O₅ 
• 1407542-46-4 C₁₆H₁₇ClN₄O₂ 
• 1408054-69-2 C₂₁H₂₆ClN₅O₃ 
• 22353-33-9 3-chloro-5-nitropyridine 

Relevant articles and documents

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors

New potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives, were designed by modeling, synthesized and evaluated in vitro. Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 μM). Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration.