14091-94-2

Usage

Appearance

Yellow solid

Molecular weight

231.29 g/mol

Uses

Versatile intermediate used in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and dyes. Commonly used as a building block in the production of antihistamine drugs and in the development of new chemical entities for potential therapeutic applications.

Synthesis

Synthesized through the reaction of 1-phenyl-2-butanone and morpholine

Structural features

Unique structural features make it a valuable component in the creation of diverse chemical structures.

Upstream product

• 110-91-8 morpholine 
• 93-91-4 1-phenylbutan-1,3-dione 
• 70769-72-1 1-phenyl-3-ethylsulfenyl-2-buten-1-one 
• 70-11-1 α-bromoacetophenone 
• 145930-93-4 4-[1-(2-Oxo-2-phenyl-ethylsulfanyl)-ethylidene]-morpholin-4-ium; bromide 
• 74896-63-2 1-phenyl-3-ethylsulfinyl-2-buten-1-one 
• 5309-93-3 N-thioacetylmorpholine 

Downstream Products

• 26930-12-1 6,6,6-trichloro-5-hydroxy-3-morpholin-4-yl-1-phenyl-hex-2-en-1-one 
• 55370-60-0 C-phenyl-C'-p-tolyl-C,C'-isoxazole-3,5-diyl-bis-methanone 
• 93326-94-4 [5-methyl-3-(4-nitro-phenyl)-isoxazol-4-yl]-phenyl-methanone 
• 53067-92-8 2-(2-acetylphenyl)-1-phenylethan-1-one 
• 1190830-89-7 5-hydroxy-1,6-diphenyl-3-(4-morpholinyl)hex-2-en-1,6-dione 
• 26826-99-3 6,6,6-trichloro-3-morpholin-4-yl-1-phenyl-5-phenylcarbamoyloxy-hex-2-en-1-one 
• 96517-67-8 4-Methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-6-phenyl-nicotinonitrile 
• 96517-63-4 (3-Cyano-4-methyl-6-phenyl-pyridin-2-ylsulfanyl)-acetic acid methyl ester 
• 96517-65-6 2-(3-Cyano-4-methyl-6-phenyl-pyridin-2-ylsulfanyl)-acetamide 

Relevant academic research and scientific papers

Reaction of arynes with vinylogous amides: Nucleophilic addition to the ortho-quinodimethide intermediate

The reaction of arynes with vinylogous amides containing no free N-H bonds proceeds in a [2 + 2] cycloaddition fashion at ambient temperature. The electronic properties of the vinylogous amides allow for the cycloadducts undergoing a facile ring-opening p

STUDY OF THE ESCHENMOSER SULFIDE CONTRACTION METHOD WITH AND WITHOUT A THIOPHILE

Results obtained and observations made by applying the title method for the synthesis of enaminones 5a-o, using triphenylphosphine as a thiophile and triethylamine as a base, are reported.The product distributions of the deprotonations of α-phenacylthio iminium bromides with and without thiophile and those known from thiouronium and heterocyclic thionium analogs are compared.Key words: Enaminones; α-phenacylthio iminium bromides; disulfides; thiiranes.