96517-64-5

Upstream product

• 54364-12-4 4-methyl-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 105-39-5 chloroacetic acid ethyl ester 
• 93-91-4 1-phenylbutan-1,3-dione 
• 18940-23-3 1-(1-morpholino)-1-phenyl-1-buten-3-one 
• 14091-94-2 3-morpholino-1-phenylbut-2-en-1-one 

Downstream Products

• 52505-64-3 3-Amino-4-methyl-6-phenyl-thieno<2,3-b>pyridin-2-carbonsaeureethylester 
• 128918-16-1 3-Amino-4-methyl-6-phenyl-thieno<2,3-b>pyridin-2-carbonsaeureamid 
• 115919-80-7 3-Amino-4-methyl-6-phenyl-thieno<2,3-b>pyridin-2-carbonsaeureamid 
• 278182-38-0 3-amino-6-phenyl-4-methylthieno[2,3-b]pyridine-2-carboxyazide 
• 58327-89-2 2,9-Dimethyl-7-phenylpyrido<3',2':4,5>thieno<3,2-d><1,3>oxazin-4-on 
• 145916-77-4 7-phenyl-9-methyl-pyrido[3',2':4,5]thieno[3,2-d]-pyrimidine-4(3H)-one 
• 128918-29-6 3-Amino-4-methyl-6-phenyl-thieno<2,3-b>pyridin-2-carbonsaeurehydrazid 
• 172878-43-2 (3-Cyano-4-methyl-6-phenyl-pyridin-2-ylsulfanyl)-fluoro-acetic acid ethyl ester 
• 148946-34-3 3-Amino-4-methyl-6-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid isopropyl ester 

Relevant academic research and scientific papers

INTEGRASE INHIBITORS - 2

The present invention provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Compounds of formula (I) are also provided.

Synthesis of novel heterocyclic compounds for antitumor and radioprotective activities

Some novel pyridothienoxazine (5); pyridothienopyrimidines (6), (8), (9), (14); pyridothienoimidazole (16); isothiazolopyridine (17), and pyridoisothiazolopyrimidines (18-20) were synthesized. The structural assignment of the prepared compounds were based on microanalytical and spectroscopic evidences. Some prepared compounds were tested in vitro for their antitumor and radioprotective activities. Compounds (7), (12), (17) and (19) showed significant activities against EAC cells, at a concentration of 250μg/ml; while the isothiazolopyridine (17) exhibited radioprotective activity.

Synthesis of N-(2-carboxy-thieno[2,3-b]pyridine-3-yl)-formamidines and corresponding alkyl esters with antianaphylactic activity

A lot of N-(2-carboxy-thieno[2,3-b]pyridin-3-yl)formamidines especially in form of their amine salts - were synthesized by reaction of 3-amino-thieno[2,3-b]pyridine-2-carboxylic acids with dimethylformamide/phosphoroxide chloride or by reaction of 4-oxo-4 H-pyrido[3',2':4,5]thieno[3,2-d]1,3-oxazines with amines. Carboxylic acid alkylesters of this structure were yielded from 3-amino-thieno[2,3-b]pyridine-2-carbonic acid alkylesters by reaction with dimethylformamide/phosphoroxide chloride or with N-formyl-piperidine or N-formyl-morpholine and phosphoroxide chloride. The compounds showed antianaphylactic activity.