52505-66-5Relevant academic research and scientific papers
Synthesis of thieno[2,3-b]pyridines with an oxalamidic acid or an oxalamidic alkylester residue and of 4-alkoxy-pyrido[3',2':4,5]thieno]3,2-d]pyrimidine-2-carboxylic acid derivatives
Wagner,Leistner,Vieweg,Krasselt,Prantz
, p. 342 - 346 (2007/10/02)
N-(2-Alkoxycarbonyl-thieno[2,3-b]pyrid-3-yl)oxalamide acid alkylester B were synthesized by the reaction of 3-amino-2-carboxylic esters A with oxalic acid diethylester in presence of sodium alkoxides. The 3-amino-2-cyano-thieno[2,3-b]pyridines C yielded under the same conditions via the N- (2-cyano-thieno[2,3-b]pyrid-3-yl)oxalamidic acid alkylesters D/1-D/4 the 4-alkoxy-pyrido[3',2': 4,5]thieno[3,2-d]pyrimidine-2-carboxylic acid alkylesters E/1-E/8. The compounds D/1, D/2 and E/1-E/5 were hydrolyzed to give the corresponding carboxylic acids. The 3-amino-furo[2,3-b]pyridine-2-carboxylic acid ethylester H reacted with oxalic ethylester chloride to give the oxalamide ethylester I. The synthesized substances showed an antianaphylactic activity.
Synthesis and antifungal activity of pyrido[3',2':4,5]thieno[3,2-d]-1,2,3-triazine derivatives
Guerrera,Salerno,Sarva,Siracusa,Oliveri,Minardi
, p. 1725 - 1733 (2007/10/02)
The antimicrobical activity of some pyrido[3'2':4,5]thieno[3,2d]-1,2,3-triazine derivatives has been studied. Some compounds proved effective against microorganisms in vitro, compounds 3a and 3c in particular exhibited antifungal activity, comparable to M
