140946-63-0Relevant academic research and scientific papers
Toxicities of 4,5-Dihydroisoxazoles against Root-Knot Nematodes and in Silico Studies of Their Modes of Action
Fráguas, Rodrigo M.,Costa, Viviane A.,Terra, Willian C.,Aguiar, Alcino P.,Martins, Samuel J.,Campos, Vicente P.,Oliveira, Denilson F.
, p. 523 - 529 (2020)
The present work sought to contribute to the development of new nematicides. Benzaldehydes were initially converted to nitrile oxides that underwent 1,3-dipolar cycloaddition reactions with methyl acrylate to generate 4,5-dihydroisoxazoles. In in vitro te
Hypervalent iodine-catalyzed cycloaddition of nitrile oxides to alkenes
Xiang, Changbin,Li, Tingting,Yan, Jie
supporting information, p. 682 - 688 (2014/01/17)
A new and convenient method for preparation of isoxazolines was developed by a catalytic cycloaddition of nitrile oxides generated in situ from aldoximes to alkenes in the presence of a catalytic amount of iodobenzene. In this protocol, iodobenzene was fi
KF/Al2O3: Solid-supported reagent used in 1,3-dipolar cycloaddition reaction of nitrile oxide
Boruah, Monalisa,Konwar, Dilip
experimental part, p. 3261 - 3268 (2012/09/11)
The stereoselective synthesis of 2-isoxazolidine through 1,3-dipolar cycloaddition reaction of nitrile oxide, which is in situ generation from aldoxime in the presence of N-bromosuccinamide and solid-supported reagent KF/Al2O3 at room temperature, is reported. KF/Al2O3 is sufficiently basic such that it can replace organic bases such as Et 3N used in typical procedures and it catalyses the reaction to enhance the rate of the reaction.
Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): Isoxazoline zinc amidase inhibitors bearing diverse metal binding groups
Pirrung, Michael C.,Tumey, L. Nathan,Raetz, Christian R. H.,Jackman, Jane E.,Snehalatha, Karnem,McClerren, Amanda L.,Fierke, Carol A.,Gantt, Stephanie L.,Rusche, Kristin M.
, p. 4359 - 4370 (2007/10/03)
UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase (LpxC) is a zinc amidase that catalyzes the second step of lipid A biosynthesis in Gram negative bacteria. Known inhibitors of this enzyme are oxazolines incorporating a hydroxamic acid at the 4-position,
