141018-99-7

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 15403-22-2 4-(3-hydroxy-propyl)-benzoic acid methyl ester 
• 151937-09-6 3-(4-methoxycarbonylphenyl)propanoic acid 
• 61266-36-2 methyl 4-(3-hydroxypropynyl)benzoate 
• 113100-81-5 4-(3-oxo-propyl)-benzoic acid methyl ester 
• 619-44-3 methyl 4-iodobenzoate 

Downstream Products

• 142979-50-8 Methyl 4-(3-iodo-1-propyl)benzoate 
• 141019-00-3 methyl 4-(3-azidopropyl)benzoate 
• 1091599-85-7 methyl 4-[3-(3,5-dichloro-6-methyl-2-oxopyridin-1(2H)-yl)propyl]benzoate 
• 169318-07-4 methyl 4-(4-cyano-4-ethoxycarbonylbutyl)benzoate 
• 142979-51-9 (3-<4-(Methoxycarbonyl)phenyl>propyl)triphenylphosphonium iodide 
• 141019-08-1 dimethyl N-<4-<3-<(2-amino-1,6-dihydro-6-oxopyrimidin-4-yl)amino>propyl>benzoyl>-l-glutamate 
• 141019-17-2 dimethyl N-<4-<3-<(2-amino-6-methoxypyrimidin-4-yl)-amino>propyl>benzoyl>-L-glutamate 
• 141019-18-3 N-<4-<3-<(2-amino-6-methoxypyrimidin-4-yl)-amino>propyl>benzoyl>-L-glutamic acid 
• 141019-09-2 N-<4-<3-<(2-amino-1,6-dihydro-6-oxopyrimidin-4-yl)amino>propyl>benzoyl>-l-glutamic acid 
• 141019-04-7 methyl 4-<3-<<6-chloro-2-(pivaloylamino)pyrimidin-4-yl>amino>propyl>benzoate 
• 141019-06-9 4-<3-<(2-amino-1,6-dihydro-6-oxopyrimidin-4-yl)amino>propyl>benzoic acid 
• 141019-16-1 4-<3-<(2-amino-6-methoxypyrimidin-4-yl)amino>propyl>benzoic acid 
• 74733-38-3 3-(4-methoxycarbonylphenyl)propylamine 

Relevant academic research and scientific papers

NOVEL PYRAZINE AMIDE COMPOUNDS

The present invention relates to compounds of formula 1 or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R4, R5, R6 and X? have the meanings as indicated in the specification, to their use as a medicament, to their use in the treatment of a disease selected from among respiratory diseases or complaints and allergic diseases of the airways, to pharmaceutical composition comprising at least one of said compound or a pharmaceutically acceptable salt thereof, as well as to medicament combinations containing one or more of said compounds or a pharmaceutically acceptable salt thereof.

NOVEL PYRAZINE AMIDE COMPOUNDS

The present invention relates to compounds of formula 1 or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R6 and X- have one of the meanings as indicated in the specification, to their use as a medicament, to their use in the treatment of a disease selected from among respiratory diseases or complaints and allergic diseases of the airways, to pharmaceutical composition comprising at least one of said compound or a pharmaceutically acceptable salt thereof, as well as to medicament combinations containing one or more of said compounds or a pharmaceutically acceptable salt thereof.

PYRIDONE COMPOUND

The present inventors have conducted extensive studies on an EP4 receptor agonist, and as a result, found that a novel pyridone compound characterized in that the 1-position in the pyridone ring is substituted with a group having an acidic group such as a

PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES

The present invention provides novel pyrimidinyl-glutamic acid derivatives and intermediates thereto. Further provided are methods for inhibiting dihydrofolate reductase in mammals and for treating susceptible neoplasms in mammals, particularly humans.

Novel 5-Desmethylene Analogues of 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid as Potential Anticancer Agents

The synthesis and biological activity of novel 5-desmethylene analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), a potent antitumor agent presently undergoing clinical trials, are described.These compounds are representative of a new series