141019-69-4Relevant academic research and scientific papers
Synthese von 2-Acetamido-1,4-imino-1,2,4-tridesoxy-D-galaktitol und kompetitive Inhibition der humanen lysosomalen β-Hexosaminidase A
Liessem, Bernhard,Giannis, Athanassios,Sandhoff, Konrad,Nieger, Martin
, p. 19 - 30 (2007/10/02)
The synthesis of 2-acetamido-1,4-imino-1,2,4-trideoxy-D-galactitol (1; 2-acetamido-4-amino-1,4-anhydro-2,4-dideoxy-D-galactitol) by two different routes starting from 2-acetamido-2-deoxy-D-glucose is described.Compound 1 is a competitive inhibitor of human lysosomal β-hexosaminidase A with Ki values of 18 μM (β-subunit) and 220 μM (α-subunit).Similar properties were found for the already known 2-acetamido-2-deoxy-D-gluco-hydroximo-1,4-lactone.
Building Units of Oligosaccharides, CII. - Synthesis of Modified Derivatives of 2-Acetamido-2-deoxy-D-galactose for the Examination of Substrate Specifities of Core 1-β3-Gal-Transferase and Core 3-β3-GlcNAc-Transferase Involved in the Biosynthesis of O-Gl
Paulsen, Hans,Rutz, Volker,Brockhausen, Inka
, p. 735 - 746 (2007/10/02)
The 2-, 3-, 4-, and 6-deoxy derivatives of benzyl 2-acetamido-2-deoxy-α-D-galactopyranoside (7) have been synthesized to test substrate specifities of glycosyltransferases involved in the biosynthesis of O-glycoproteins.The core 1-β3-Gal-transferase does
