141034-22-2Relevant academic research and scientific papers
SYNTHESIS OF trans-2-IMINOTHIAZOLIDINE AND RELATED COMPOUNDS - A NEW CLASS OF ANTIDEPRESSANTS
Shukla, Upendra K.,Singh, Raieshwar,Khanna, J. M.,Saxena, Anil K.,Singh, Hemant K.,et al.
, p. 415 - 424 (2007/10/02)
Antiparasitic and antidepressant activities exhibited by tetramisole (I) and its enantiomers prompted the study of its structural analogs trans-2-iminothiazolidine (VIII/IX) and 2,3,4a,5,6,10b-hexahydronaphthoimidazothiazole (XII), 2,3,4a,5-tetrahydro-9bH-indenoimidazothiazole (XIII), and 2,3,4a,5-tetrahydro-9bH-indenoimidazothiazole (XVI), and a homolog 3,4,6,7-tetrahydro-7-phenyl-2H-imidazo-1,3-thiazine (XX).While none of these compounds showed any noteworthy antiparasitic activity, the trans-2-iminothiazolidine (VIII) has shown marked antidepressant activity, better than imipramine in the tests used, and provides a new structural lead for antidepressants.
Substituted imidazo thiazoles thiazines, thiazepines and thiazocines
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, (2008/06/13)
Disclosed herein are novel tetrahydro imidazo thiazoles, tetrahydro imidazo thiazines, hexahydro imidazo thiazepines and hexahydro imidazo thiazocines, intermediates for the preparation thereof, methods of using the compounds as anti-inflammatory agents and methods of using an intermediate thereof as anti-secretory agents to relieve the symptoms of gastric distress.
