49704-08-7

Upstream product

• 75-15-0 carbon disulfide 
• 5700-56-1 1,2-diaminophenylethane 

Downstream Products

• 89446-81-1 2-β-Diethylaminoethylthio-4-phenyl-Δ²-imidazoline 
• 141034-22-2 7-phenyl-3,4,6,7-tetrahydro-2H-imidazo<2,1-b>-(1,3)-thiazine 
• 89467-22-1 Diethyl-[3-(4-phenyl-4,5-dihydro-1H-imidazol-2-ylsulfanyl)-propyl]-amine 
• 89446-85-5 2-Phenethylsulfanyl-4-phenyl-4,5-dihydro-1H-imidazole 
• 89446-82-2 4-Phenyl-2-(2-pyrrolidin-1-yl-ethylsulfanyl)-4,5-dihydro-1H-imidazole 
• 89446-83-3 1-[2-(4-Phenyl-4,5-dihydro-1H-imidazol-2-ylsulfanyl)-ethyl]-piperidine 
• 89446-87-7 1-Phenyl-2-(4-phenyl-4,5-dihydro-1H-imidazol-2-ylsulfanyl)-ethanone 
• 89446-84-4 2-(2-Phenoxy-ethylsulfanyl)-4-phenyl-4,5-dihydro-1H-imidazole 
• 89446-86-6 2-(2-Benzyloxy-ethylsulfanyl)-4-phenyl-4,5-dihydro-1H-imidazole 

Relevant academic research and scientific papers

IMIDAZOLINE DERIVATIVES AS CXCR4 MODULATORS

The present invention provides novel compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds of formula (I) can act as CXCR4 modulators that specifically target the CXCR4 minor pocket, and they have further been

Method of making imidazole-2-thiones

The present invention provides a method of making an imidazole-2-thione which comprises the steps of reacting a vicinal diamine with a compound having a thiocarbonyl moiety and oxidizing the resulting reaction product to obtain said imidazole-2-thione.

Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups

New histamine H3-receptor antagonists were synthesised and tested on rat brain membranes and on electrically stimulated guinea-pig ileum. The new compounds have a central polar group represented by a 2-alkylimidazole or a 2-thioimidazoline nucleus. The effect of the polar group basicity on the optimal length of the alkyl chain, connecting this group to a 4(5)-imidazolyl ring, was investigated. The best affinity values, obtained by displacement of [3H]-RAMHA from rat brain, were obtained for the 2-alkylimidazole derivatives (2a-f) with tetramethylene chain (pK(i) 8.03-8.97), having an intermediate basicity between that of the previously reported 2- thioimidazoles (1a-i) and that of 2-alkylthioimidazolines (3a-h). In contrast, a general lowering of affinity (pK(i) 5.90-7.63) was observed for compounds of the last series (3a-h), with a complex dependence on the terminal lipophilic group and chain length. (C) 2000 Elsevier Science S.A.

SYNTHESIS OF trans-2-IMINOTHIAZOLIDINE AND RELATED COMPOUNDS - A NEW CLASS OF ANTIDEPRESSANTS

Antiparasitic and antidepressant activities exhibited by tetramisole (I) and its enantiomers prompted the study of its structural analogs trans-2-iminothiazolidine (VIII/IX) and 2,3,4a,5,6,10b-hexahydronaphthoimidazothiazole (XII), 2,3,4a,5-tetrahydro-9bH-indenoimidazothiazole (XIII), and 2,3,4a,5-tetrahydro-9bH-indenoimidazothiazole (XVI), and a homolog 3,4,6,7-tetrahydro-7-phenyl-2H-imidazo-1,3-thiazine (XX).While none of these compounds showed any noteworthy antiparasitic activity, the trans-2-iminothiazolidine (VIII) has shown marked antidepressant activity, better than imipramine in the tests used, and provides a new structural lead for antidepressants.