141075-87-8

Usage

Uses

Used in Chemical Synthesis:
Benzene, [(1-fluoroethenyl)thio]is used as an intermediate in the synthesis of 13-Fluorodibenzo[a,i]pyrene (F588440), a compound with potential applications in various chemical and pharmaceutical industries. The synthesis process involves the activation of P450 mono-oxygenase enzymes, which play a crucial role in the metabolism and detoxification of various compounds.
Used in Research and Development:
Due to its unique electrical and optical properties, Benzene, [(1-fluoroethenyl)thio]can be utilized in the development of novel materials and devices in the fields of electronics, optoelectronics, and photonics. Its conjugated macromolecular structure allows for the exploration of its potential in creating advanced materials with improved performance and functionality.
Used in Environmental and Health Studies:
As a polycyclic aromatic hydrocarbon (PAH), Benzene, [(1-fluoroethenyl)thio]can be used in research aimed at understanding the environmental and health impacts of PAHs. This includes studying their carcinogenic properties, their behavior in the environment, and their potential effects on human health.
Used in Pharmaceutical Industry:
Although Benzene, [(1-fluoroethenyl)thio]itself may not be directly used as a pharmaceutical compound, its synthesis intermediate, 13-Fluorodibenzo[a,i]pyrene (F588440), could potentially be utilized in the development of new drugs or drug candidates. Further research and development in this area could lead to the discovery of novel therapeutic agents with improved efficacy and safety profiles.

Upstream product

• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 257610-49-4 (α-Fluorovinyl)diphenylmethylsilane 
• 6228-98-4 phenylthioacetylene 
• 63139-23-1 phenylthioethynyl trimethylsilane 
• 882-33-7 diphenyldisulfane 
• 358-98-5 1,2-dibromo-1-fluoro-ethene 
• 108-98-5 thiophenol 

Downstream Products

• 114969-03-8 (1-fluoroethenyl)phenylsulfane dioxide 
• 1451049-49-2 CF₃O₃S^(1-)*C₁₄H₁₂FS⁽¹⁺⁾ 
• 515863-85-1 (1-fluorovinyl) phenyl sulfoxide 

Relevant academic research and scientific papers

Fluorovinyl Thioethers as Putative Steric and Electronic Thioester Enolate Mimetics: Chemoselective HF Addition to Acetylene Thioethers

Fluorovinyl thioethers are presented as a putative biomimetic surrogate for the enol/ate of a thioester. A method is explored for the preparation of fluorovinyl thioethers by treatment of acetylene thioethers with pyridinium (poly)-hydrogen fluoride. Titr

LPA RECEPTOR ANTAGONISTS AND USES THEREOF

The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).

Synthesis and reactivity of (1-fluorovinyl) phenyl sulfoxide as a dienophile

(1-Fluorovinyl) phenyl sulfoxide 2 was prepared in two steps from (1-fluorovinyl)methyldiphenylsilane. Although the sulfoxide 2 underwent Diels-Alder reaction with very reactive diene, 1,3-diphenylisobenzofuran, to give the corresponding fluorinated-napht

NUCLEOPHILIC REACTIONS AT A VINYL CENTER. XXIII. REACTIONS OF BROMOFLUOROETHYLENES WITH SODIUM BENZENETHIOLATE

The reactions of a number of bromofluoroethylenes with sodium benzenethiolate were investigated.The reactions go regioselectively.The phenylthio group adds to the carbon linked to a fluorine atom.With CF2=CHBr the addition product PhSCF2CH2Br is formed.The alkene CHBr=CHF does not react with PhSNa even after prolonged boiling in ethanol.The alkene CBr2=CHF gives a 1:2 mixture of the Z and E isomers of PhSCF=CHBr.The composition of the products of the reaction of PhSNa with the Z and E isomers of CFBr=CHBr depends on its isomeric composition.The Z isomer gives the product of nucleophilic vinyl substitution with the preservation of the configuration, the Z isomer of PhSCF=CHBr, whereas the E isomer gives products of halophilic reduction, PhSCF=CH2 and PhSSPh, and in smaller amounts also products of vinyl substitution both with the preservation, but also with the inversion, of the configuration, the Z and E isomers of PhSCF=CHBr.The alkene CFBr=CBr2 reacts smoothly to give only the product of nucleophilic vinyl substitution, PhSCF=CBr2.All the sulfides obtained were oxidized to sulfones.The structures of the compounds were established by means of 1H, 13C, and 19F NMR and, in the case of the E isomer of PhSO2CF=CHBr by x-ray structure analysis.