14108-76-0

Basic information

• Product Name: ETHYL 2-(4-IODOANILINO)ACETATE
• Synonyms: ETHYL 2-(4-IODOANILINO)ACETATE;Ethyl [(4-iodophenyl)amino]acetate;Ethyl [(4-iodophenyl)amino]acetate 97%;Ethyl[(4-iodophenyl)amino]acetate97%;ethyl N-(4-iodophenyl)glycinate
• CAS NO: 14108-76-0
• Molecular Formula: C₁₀H₁₂INO₂
• Molecular Weight: 305.11
• Mol File: 14108-76-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 84-86
• Boiling Point: 339.8°Cat760mmHg
• Flash Point: 159.3°C
• Appearance: /
• Density: 1.658g/cm³
• Vapor Pressure: 8.99E-05mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: ETHYL 2-(4-IODOANILINO)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(4-IODOANILINO)ACETATE(14108-76-0)
• EPA Substance Registry System: ETHYL 2-(4-IODOANILINO)ACETATE(14108-76-0)

Safety Data

• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 14108-76-0(Hazardous Substances Data)

Usage

General Description

ETHYL 2-(4-IODOANILINO)ACETATE is a chemical compound with the formula C11H12INO2. It is an ethyl ester of 2-(4-iodoanilino)acetic acid, which is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. ETHYL 2-(4-IODOANILINO)ACETATE is a white to off-white solid with a molecular weight of 307.12 g/mol. In its liquid form, it has a density of 1.56 g/cm3 and a boiling point of 340.8°C. ETHYL 2-(4-IODOANILINO)ACETATE is a versatile and valuable chemical for various industrial and research applications, particularly in the field of drug development and organic synthesis.

InChI:InChI=1/C10H12INO2/c1-2-14-10(13)7-12-9-5-3-8(11)4-6-9/h3-6,12H,2,7H2,1H3

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 540-37-4 p-aminoiodobenzene 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1313757-66-2 N-((4-ethynyl)phenyl)glycine ethyl ester 
• 1361147-63-8 N-((4-trimethylsilylethynyl)phenyl)glycine ethyl ester 
• 13370-63-3 2-((4-iodophenyl)amino)acetic acid 

Relevant articles and documents

Ethyl cellulose derived porous iron@N-doped carbon material for N–H carbene insertion reaction

A newly developed, facile and sustainable strategy, in which zinc salt, melamine and ethyl cellulose are applied as pore-forming agent, nitrogen and carbon source respectively, has been disclosed for the synthesis of Fe/N-codoped carbon materials. This material exhibits excellent catalytic efficiency towards N–H carbene insertion reaction for the synthesis of unnatural amino acid derivatives. Fe/FeOx nanoparticles tranfer electrons to N-doped carbon owing to the Mott-Schottky Effect, which is beneficial to the formation of iron carbene intermediate. N-doping can offer more Lewis base sites, which promotes the proton transfer process. Fe/FeOx nanoparticles are coated with graphitic carbon, thereby avoiding the loss and deactivation of iron sites in this material. Therefore, this material can be reused at least four times without significant loss in activity.

Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage

So far, there is still no specific drug against COVID-19. Taking compound 1 with anti-EBOV activity as the lead, fifty-four 12N-substituted aloperine derivatives were synthesized and evaluated for the anti-SARS-CoV-2 activities using pseudotyped virus model. Among them, 8a exhibited the most potential effects against both pseudotyped and authentic SARS-CoV-2, as well as SARS-CoV and MERS-CoV, indicating a broad-spectrum anti-coronavirus profile. The mechanism study disclosed that 8a might block a late stage of viral entry, mainly via inhibiting host cathepsin B activity rather than directly targeting cathepsin B protein. Also, 8a could significantly reduce the release of multiple inflammatory cytokines in a time- and dose-dependent manner, such as IL-6, IL-1β, IL-8 and MCP-1, the major contributors to cytokine storm. Therefore, 8a is a promising agent with the advantages of broad-spectrum anti-coronavirus and anti-cytokine effects, thus worthy of further investigation.

Stable radical cation salt initiated N-H insertion and related proton-transfer-delay three-component reaction

The N-H insertion reaction forms the single addition product exclusively, and does not require slow addition of the diazo component. More importantly, we present the reaction of anilines with both diazoacetates and azodicarboxylates in the presence of catalytic amounts of triarylaminium salt giving the corresponding complex unsymmetrical aminals in high yields. This is the first example of stable radical cation salt promoted proton-transfer-delay three-component reaction.