1413060-46-4

Basic information

• Product Name: 5-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide
• Synonyms: 5-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide
• CAS NO: 1413060-46-4
• Molecular Weight: 435.455
• Mol File: 1413060-46-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide(1413060-46-4)
• EPA Substance Registry System: 5-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide(1413060-46-4)

Safety Data

• Hazardous Substances Data: 1413060-46-4(Hazardous Substances Data)

Upstream product

• 1413063-98-5 acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-(5-carbamoyl-furan-2-yl)-benzyl ester 
• 1413063-73-6 acetic acid 2-bromo-6-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-benzyl ester 
• 1242156-76-8 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate 
• 1147858-83-0 acetic acid 2,6-dibromobenzyl ester 
• 93701-32-7 2,6-dibromobenzyl bromide 
• 69321-60-4 2,6-dibromotoluene 

Relevant articles and documents

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.