1413063-98-5

Basic information

• Product Name: acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-(5-carbamoyl-furan-2-yl)-benzyl ester
• Synonyms: acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-(5-carbamoyl-furan-2-yl)-benzyl ester
• CAS NO: 1413063-98-5
• Molecular Weight: 477.492
• Mol File: 1413063-98-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-(5-carbamoyl-furan-2-yl)-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-(5-carbamoyl-furan-2-yl)-benzyl ester(1413063-98-5)
• EPA Substance Registry System: acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-(5-carbamoyl-furan-2-yl)-benzyl ester(1413063-98-5)

Safety Data

• Hazardous Substances Data: 1413063-98-5(Hazardous Substances Data)

Upstream product

• 1413063-73-6 acetic acid 2-bromo-6-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-benzyl ester 
• 1147858-83-0 acetic acid 2,6-dibromobenzyl ester 
• 6134-61-8 5-bromo-furan-2-carboxylic acid amide 
• 1242156-76-8 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate 
• 93701-32-7 2,6-dibromobenzyl bromide 
• 69321-60-4 2,6-dibromotoluene 

Downstream Products

• 1413060-46-4 5-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide 

Relevant articles and documents

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.