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Relevant academic research and scientific papers

A new one-pot synthesis of α-amino phosphonates catalyzed by butyldimethyl(1-phenylethyl)ammonium bromide

Butyldimethyl(1-phenylethyl)ammonium bromide is found to be an efficient catalyst for the three-component reaction of an aldehyde, aromatic amine, and trimethylphosphite in refluxing CH2Cl2 to afford corresponding α-amino phosphonate in high yield. Copyright

Polyaniline coated glass/SS sheet: Novel, convenient, efficient, reusable and green catalyst

Polyaniline containing methanesulfonic acid dopant in semi crystalline with nano fiber morphology was synthesized easily in one step with excellent yield (1.26 g with respect to 1 g of aniline used), pellet density (1.32 g/cm 3), and reasonably good conductivity (8.6 S/cm). PANI-MSA, formed in organic carrier solvent in the polymerization reaction, was coated on glass slide/glass rod/stainless steel sheet and used as novel reusable polymer based solid acid catalyst in the synthesis of α-aminophosphonates with excellent yields and the same glass slide was used for the preparation of various α-aminophosphonates.

Bismuth(III) chloride-catalyzed three-component coupling: Synthesis of α-amino phosphonates

A simple and efficient method has been developed for the one-pot synthesis of α-amino phosphonates from the reaction of a carbonyl compound, amine, and dialkyl phosphite. The highly catalytic nature of bismuth(III) chloride and the fact that it is relatively nontoxic, low cost, easy to handle, and insensitive to small amounts of air and moisture make this method especially attractive for large-scale synthesis. Copyright Taylor & Francis, Inc.

CAL-B accelerated novel synthetic protocols for 3,3’-arylidenebis-4-hydroxycoumarins and dimethyl ((substituted phenyl) (phenylamino)methyl) phosphonates

Green protocols for the syntheses of 3,3′-arylidenebis-4-hydroxycoumarins and dimethyl ((substituted phenyl) (phenylamino)methyl) phosphonates have been first time developed using biocatalyst, CAL-B (lipase). These are carried at room temperature under st

Method for preparing alpha-phosphoramidate compound

The invention provides a method for preparing an alpha-phosphoramidate compound. The method comprises the step of subjecting aromatic aldehyde, amine and phosphite to a tri-ingredient domino reactionunder the condition of ionic liquid, thereby preparing the alpha-phosphoramidate compound. The process conditions are simple, the operability is high, and thus, a novel scheme is provided for large-scale production of the alpha-phosphoramidate compound.

Formic acid catalyzed one-pot synthesis of α-aminophosphonates: an efficient, inexpensive and environmental friendly organocatalyst

Abstract: Aqueous formic acid is used for the synthesis of α-aminophosphonates through Kabachnik–Fields reaction applying aromatic amine, phosphite, and carbonyl compounds. Using formic acid as an efficient and low-cost organocatalyst provides environmental friendly, high yields, low reaction time and mild reaction condition. The isolated products were analyzed by IR, NMR, and mass techniques. Graphical abstract: [Figure not available: see fulltext.].

Synthesis of α-aminophosphonates in the presence of triethylammonium hydrogen sulfate [Et3NH][HSO4] as a highly efficient ionic liquid catalyst

Triethylammonium hydrogen sulfate was used as a cheap and mild acidic ionic liquid for efficient, one-pot, three-component reaction of aldehydes, amines and trimethyl phosphite. Thus α-aminophosphonates were synthesized at room temperature in excellent yields. The ionic liquid catalyst is air and water stable, easy to prepare from amine and acid and easily separated from the reaction mixture. (Chemical Equation Presented).

A new procedure for synthesis of α -aminophosphonates by aqueous formic acid as an effective and environment-friendly organocatalyst

Abstract: Aqueous formic acid (37%) as a green organocatalyst was used to synthesis of α -aminophosphonates in one-pot, three-component Kabachnik–Fields reaction. The structures of compounds were determined by FT-IR, 1H -NMR and 13C -NMR spectroscopy. After optimization of the experimental?conditions, the reaction was carried out at 65°C under solvent- free condition. Use of a nontoxic effective organocatalyst, easy work up process and low-cost cleaning procedure are from the main advantages of this research. Graphical Abstract: Synthesis and characterization of α -aminophosphonates in one-pot, three-component Kabachnik–Fields reaction by formic acid in solvent free condition are reported. Using of a nontoxic effective organocatalyst, easy work up process and low-cost cleaning procedure are from the main advantages of this research.

Highly efficient solvent free synthesis of α-aminophosphonates catalyzed by recyclable nano-magnetic sulfated zirconia (Fe3O4@ZrO2/SO42-)

In this project, nano-magnetic sulfated zirconia Fe3O4@ZrO2/SO42- was prepared and characterized using various instrumental methods. Sulfated zirconia supported on magnetic nanoparticles can act as a well-organized nanocatalyst and can be easily separated from the reaction mixture using an external magnetic field. Nano-Fe3O4@ZrO2/SO42- is a heterogeneous acidic catalyst and has particular advantages such as a facile synthesis procedure, high activity, easy separation and reusability. It was applied as an efficient nanocatalyst in the synthesis of α-aminophosphonate derivatives in the Kabachnik-Fields reaction. This synthetic method has several advantages including high yields, short reaction times, easy workup and environmentally benign reaction conditions.

A green protocol for one-pot three-component synthesis of α-amino phosphonates catalyzed by succinic acid

A simple, efficient, and general method has been developed for the one-pot, three-component synthesis of α-amino phosphonates from a condensation reaction of trialkyl phosphite, aldehydes, and amines in the presence of a catalytic amount of succinic acid (8.5 mol %) (for the first time) under solvent-free conditions. The advantages of this protocol are excellent yields, short reaction time, mild reaction conditions, higher availability, low costs, more environmentally friendly, lack of need for column chromatography and simple work-up procedure. Graphical Abstract: [Figure not available: see fulltext.]