141397-59-3Relevant academic research and scientific papers
Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: Synthesis and in vitro biological evaluation
Rosowsky,Forsch,Reich,Freisheim,Moran
, p. 1578 - 1588 (2007/10/02)
5-Deazafolate and 5-deazatetrahydrofolate (DATHF) analogues with the glutamic acid side chain replaced by homocysteic acid (HCysA), 2-amino-4- phosphonobutanoic acid (APBA), and ornithine (Orn) were synthesized as part of a larger program directed toward
Synthesis and Biological Evaluation of Nα-(5-Deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine
Singh, Shyam K.,Singer, Sara C.,Ferone, Robert,Waters, Kathleen A.,Mullin, Robert J.,Hynes, John B.
, p. 2002 - 2006 (2007/10/02)
A novel folic acid analogue, Nα-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine, 3, was prepared via a multistep synthetic sequence.The key steps involved the conversion of 5-deazapteroic acid to its N10-formyl derivative followed by
