14149-31-6 Usage
Uses
Used in Pharmaceutical Research and Development:
4-Phenylpiperidine-2,6-dione is used as a precursor in the synthesis of pharmaceuticals for its versatile reactivity and potential to produce a wide range of derivatives with various biological activities. Its ability to form diverse compounds makes it a valuable component in the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Phenylpiperidine-2,6-dione is used as a key intermediate for the production of various organic compounds. Its unique structure and reactivity allow for the creation of a broad spectrum of molecules with different properties and applications, making it an essential component in the synthesis of specialty chemicals and materials.
Used in Chemical Research:
4-Phenylpiperidine-2,6-dione is utilized in chemical research as a model compound to study the properties and reactions of cyclic imides. Its mild irritant and corrosive properties, along with its solubility characteristics, make it an interesting subject for investigations into chemical behavior, reactivity, and potential applications in various industries.
Used in Drug Development:
In the drug development industry, 4-Phenylpiperidine-2,6-dione is employed as a building block for the creation of new pharmaceutical compounds. Its ability to form derivatives with diverse biological activities contributes to the discovery and development of innovative drugs for the treatment of various diseases and medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 14149-31-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,1,4 and 9 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14149-31:
(7*1)+(6*4)+(5*1)+(4*4)+(3*9)+(2*3)+(1*1)=86
86 % 10 = 6
So 14149-31-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H11NO2/c13-10-6-9(7-11(14)12-10)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,12,13,14)
14149-31-6Relevant academic research and scientific papers
COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF
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Paragraph 0367-0368, (2020/07/07)
It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.
Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α1-adrenoceptor subtypes
Romeo, Giuseppe,Materia, Luisa,Modica, Maria N.,Pittalà, Valeria,Salerno, Loredana,Siracusa, Maria A.,Manetti, Fabrizio,Botta, Maurizio,Minneman, Kenneth P.
experimental part, p. 2676 - 2690 (2011/07/08)
A number of new 4-phenylpiperidine-2,6-diones bearing at the 1-position an ω-[4-(substituted phenyl)piperazin-1-yl]alkyl moiety were designed and synthesized as ligands for the α1-adrenergic receptor (α1-AR) subtypes. Some synthesized compounds, tested in binding assays for the human cloned α1A-, α1B-, and α1D-AR subtypes, displayed affinities in the nanomolar range. Highest affinity values were found in derivatives having a butyl connecting chain between the 4-phenylpiperidine-2,6-dione and the phenylpiperazinyl moieties. 1-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]-4-phenylpiperidine-2,6- dione (34) showed the best affinity for the α1A-AR (pKi= 8.74) and 10-fold selectivity compared to the other two α1-AR subtypes. Some representative compounds were also tested in order to evaluate their effects on the signal transduction pathway coupled to α1-AR subtypes. They all blocked norepinephrine-induced stimulation of inositol phospholipid hydrolysis, thus behaving as antagonists. Binding data were used to refine a previously developed pharmacophoric model for α1D-ARs. The revised model shows a highly predictive power and could be useful for the future design of high affinity α1D-AR ligands.
