1414976-36-5

Basic information

• Product Name: C₁₅H₁₉NO₂
• Synonyms: C₁₅H₁₉NO₂
• CAS NO: 1414976-36-5
• Molecular Weight: 245.321
• Mol File: 1414976-36-5.mol

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₉NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₉NO₂(1414976-36-5)
• EPA Substance Registry System: C₁₅H₁₉NO₂(1414976-36-5)

Safety Data

• Hazardous Substances Data: 1414976-36-5(Hazardous Substances Data)

Upstream product

• 1292320-79-6 (1R,2R)-2-(nitromethyl)cyclopentane-1-carbaldehyde 
• 629-11-8 1,6-hexanediol 
• 1414976-22-9 C₉H₁₅NO₄ 
• 6140-65-4 1-cyclopentene-1-carboxaldehyde 
• 1414976-35-4 C₁₅H₁₈N₂ 
• 1414976-28-5 C₁₆H₂₃NO₂ 
• 1414976-24-1 C₉H₁₇NO₂ 

Downstream Products

• 926276-11-1 (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid 
• 714194-68-0 tert-butyl (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylate 
• 1414976-37-6 C₁₉H₂₇NO₂ 
• 402959-36-8 C₃₆H₅₅N₇O₆ 
• 402957-28-2 (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide 

Relevant articles and documents

Asymmetric synthesis of 3,4-disubstituted proline derivatives: Application in synthesis of hepatitis C virus protease inhibitor telaprevir

A practical asymmetric synthesis of 3,4-disubstituted proline derivatives has been realized with high stereoselectivity and moderate yield. The key steps involved are desymmetric ring-opening reaction of commercially available anhydrides, intramolecular Strecker reaction and thermodynamically controlled cyanide hydrolysis. Based on this methodology, the synthesis of HCV protease inhibitor Telaprevir was achieved.

PROCESS FOR PRODUCING ESTER COMPOUND

Compound (1) or a salt that is useful as an intermediate for the production of a medicine, an agrochemical or the like can be produced by a process including the following steps: (A) reacting an aldehyde (2) with nitromethane to produce a nitroaldehyde; (B) reacting the nitroaldehyde with an alcohol to produce a nitroacetal; (C) reducing the nitroacetal to produce an aminoacetal; (D) protecting an amino group in the aminoacetal to produce a protected aminoacetal; (E) treating the protected aminoacetal with an acid and subsequently with a base and then reacting the resultant product with a cyanating agent to produce a nitrile; (F) hydrolyzing the nitrile to produce a protected amino acid; and (G) substituting a group R5 in the protected amino acid by a hydrogen atom and protecting a carboxyl group therein.