1414976-35-4

Upstream product

• 1414976-24-1 C₉H₁₇NO₂ 
• 773837-37-9 sodium cyanide 
• 1414976-28-5 C₁₆H₂₃NO₂ 
• 7677-24-9 trimethylsilyl cyanide 
• 1292320-79-6 (1R,2R)-2-(nitromethyl)cyclopentane-1-carbaldehyde 
• 629-11-8 1,6-hexanediol 
• 1414976-22-9 C₉H₁₅NO₄ 
• 6140-65-4 1-cyclopentene-1-carboxaldehyde 

Downstream Products

• 1414976-36-5 C₁₅H₁₉NO₂ 
• 1414976-37-6 C₁₉H₂₇NO₂ 
• 714194-68-0 tert-butyl (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylate 

Relevant academic research and scientific papers

PROCESS FOR PRODUCING ESTER COMPOUND

Compound (1) or a salt that is useful as an intermediate for the production of a medicine, an agrochemical or the like can be produced by a process including the following steps: (A) reacting an aldehyde (2) with nitromethane to produce a nitroaldehyde; (B) reacting the nitroaldehyde with an alcohol to produce a nitroacetal; (C) reducing the nitroacetal to produce an aminoacetal; (D) protecting an amino group in the aminoacetal to produce a protected aminoacetal; (E) treating the protected aminoacetal with an acid and subsequently with a base and then reacting the resultant product with a cyanating agent to produce a nitrile; (F) hydrolyzing the nitrile to produce a protected amino acid; and (G) substituting a group R5 in the protected amino acid by a hydrogen atom and protecting a carboxyl group therein.

Asymmetric synthesis of 3,4-disubstituted proline derivatives: Application in synthesis of hepatitis C virus protease inhibitor telaprevir

A practical asymmetric synthesis of 3,4-disubstituted proline derivatives has been realized with high stereoselectivity and moderate yield. The key steps involved are desymmetric ring-opening reaction of commercially available anhydrides, intramolecular Strecker reaction and thermodynamically controlled cyanide hydrolysis. Based on this methodology, the synthesis of HCV protease inhibitor Telaprevir was achieved.