1415564-64-5Relevant academic research and scientific papers
Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)
Tan, Li,Nomanbhoy, Tyzoon,Gurbani, Deepak,Patricelli, Matthew,Hunter, John,Geng, Jiefei,Herhaus, Lina,Zhang, Jianming,Pauls, Eduardo,Ham, Youngjin,Choi, Hwan Geun,Xie, Ting,Deng, Xianming,Buhrlage, Sara J.,Sim, Taebo,Cohen, Philip,Sapkota, Gopal,Westover, Kenneth D.,Gray, Nathanael S.
, p. 183 - 196 (2015)
We developed a pharmacophore model for type II inhibitors that was used to guide the construction of a library of kinase inhibitors. Kinome-wide selectivity profiling of the library resulted in the identification of a series of 4-substituted 1H-pyrrolo[2,
