182369-73-9

Basic information

• Product Name: rac 5-Desfluoro Voriconazole
• Synonyms: rac 5-Desfluoro Voriconazole ;(+/-)-DesMonofluono Voriconazole;(R*,S*)-α-(2,4-Difluorophenyl)-β-Methyl-α-(1H-1,2,4-triazol-1-ylMethyl)-4-pyriMidineethanol;Voriconazole IMpurity B;(2RS,3SR)-2-(2,4-Difluorophenyl)-3-pyrimidin-4-yl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• CAS NO: 182369-73-9
• Molecular Formula: C16H15F2N5O
• Molecular Weight: 331.3200064
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 182369-73-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 513.3±60.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 11.76±0.29(Predicted)
• CAS DataBase Reference: rac 5-Desfluoro Voriconazole(CAS DataBase Reference)
• NIST Chemistry Reference: rac 5-Desfluoro Voriconazole(182369-73-9)
• EPA Substance Registry System: rac 5-Desfluoro Voriconazole(182369-73-9)

Safety Data

• Hazardous Substances Data: 182369-73-9(Hazardous Substances Data)

Usage

Uses

Voriconazole

Upstream product

• 30537-73-6 4-ethylpyrimidine 
• 109-72-8 n-butyllithium 
• 86404-63-9 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone 
• 188416-44-6 3-(4-chloropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 124703-78-2 6-ethylpyrimidin-4-ol 
• 141602-25-7 4-chloro-6-ethylpyrimidine 
• 288-88-0 1,2,4-Triazole 
• 124-63-0 methanesulfonyl chloride 

Relevant articles and documents

Synthesis method of voriconazole impurity B

The invention relates to a synthesis method of a voriconazole impurity B. The synthesis method of the voriconazole impurity B comprises the steps of firstly, dissolving formamidine acetate and sodiumtert-butoxide in methyl alcohol, conducting stirring und

Novel antifungal 2-aryl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus

Replacement of one triazole ring of fluconazole with 4-pyridinyl leads to an increase in activity against Aspergillus fumigatus. Introduction of an α-methyl group has a marked additional beneficial effect. Investigation of pyridinyl and pyrimidinyl analogues resulted in the identification of 30 (UK-109,496), voriconazole) which has excellent potency against a broad range of fungal pathogens including A. fumigatus and Candida krusei.