1416970-54-1Relevant articles and documents
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia
Ko?aczkowski, Marcin,Marcinkowska, Monika,Bucki, Adam,?niecikowska, Joanna,Paw?owski, Maciej,Kazek, Grzegorz,Siwek, Agata,Jastrz?bska-Wi?sek, Magdalena,Partyka, Anna,Wasik, Anna,Weso?owska, Anna,Mierzejewski, Pawe?,Bienkowski, Przemyslaw
supporting information, p. 221 - 235 (2015/06/30)
We describe a novel class of designed multiple ligands (DMLs) combining serotonin 5-HT6 receptor (5-HT6R) antagonism with dopamine D2 receptor (D2R) partial agonism. Prototype hybrid molecules were designed usin
INDOLEAMINE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES
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Page/Page column 2-21, (2013/03/26)
Indoleamine derivatives of formula (IA), wherein R1 represents benzyl unsubstituted or substituted with halogen atom, -OH, or C1-C3-alkyl; phenylsulphonyl unsubstituted or substituted in the phenyl ring with halogen atom, -OH or C1-C3-alkyl; G1 represents phenoxyalkyl, heteroaryloxyalkyl- or heterocyclyloxyalkyl-piperazine moiety; and pharmaceutically acceptable salts and solvates thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders.