14173-41-2

Basic information

• Product Name: 4-Iodo-DL-phenylalanine
• Synonyms: 4-IODO-DL-PHENYLALANINE;DL-4-IODOPHENYLALANINE;H-DL-PHE(P-I)-OH;H-DL-PHE(4-I)-OH;H-P-IODO-DL-PHE-OH;P-IODO-DL-PHENYLALANINE;DL-4-Iodophenylalanine 4-Iodo-DL-Phenyl Alanine;4-Lodo-DL-phenylalanine
• CAS NO: 14173-41-2
• Molecular Formula: C₉H₁₀INO₂
• Molecular Weight: 291.09
• Product Categories: Benzenes
• Mol File: 14173-41-2.mol
• Article Data: 32

Chemical Properties

• Melting Point: 276°C
• Boiling Point: 366.8 °C at 760 mmHg
• Flash Point: 175.6 °C
• Appearance: /
• Density: 1.824 g/cm³
• Vapor Pressure: 5.01E-06mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: Store at RT.
• CAS DataBase Reference: 4-Iodo-DL-phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Iodo-DL-phenylalanine(14173-41-2)
• EPA Substance Registry System: 4-Iodo-DL-phenylalanine(14173-41-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 14173-41-2(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C9H10INO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)

Upstream product

• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 76410-58-7 p-borono-L-phenylalanine 
• 62040-55-5 p-amino-L-phenylalanine hydrochloride 
• 63-91-2 L-phenylalanine 
• 150-30-1 Phenylalanine 

Downstream Products

• 113850-77-4 (S)-methyl 2-amino-3-(4-iodophenyl)propanoate 
• 143508-14-9 (S)-2-[(R)-(1-Aza-bicyclo[2.2.2]oct-3-yl)amino]-3-(4-iodo-phenyl)-propionic acid 
• 143508-14-9 (S)-2-[(S)-(1-Aza-bicyclo[2.2.2]oct-3-yl)amino]-3-(4-iodo-phenyl)-propionic acid 
• 222854-50-4 (L)-4-iodophenylalanine t-butyl ester 
• 115820-04-7 N-trifluoroacetyl-4-iodophenylalanine 

Relevant articles and documents

Palladium-mediated site-selective Suzuki-Miyaura protein modification at genetically encoded aryl halides

Site-specific genetic incorporation of unnatural p-halophenylalanine amino acid residues as 'tags' coupled with Pd(0)-mediated Suzuki-Miyuara 'modification' has been enabled by discovery of an effective small molecule palladium scavenger.

Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes

The development of a synthetic code that enables a sequence programmable feature like DNA represents a key aspect toward intelligent molecular systems. We developed herein the well-known dynamic covalent interaction between boronic acids (BAs) and catechols (CAs) into synthetic nucleobase analogs. Along a defined peptide backbone, BA or CA residues are arranged to enable sequence recognition to their complementary strand. Dynamic strand displacement and errors were elucidated thermodynamically to show that sequences are able to specifically select their partners. Unlike DNA, the pH dependency of BA/CA binding enables the dehybridization of complementary strands at pH 5.0. In addition, we demonstrate the sequence recognition at the macromolecular level by conjugating the cytochrome c protein to a complementary polyethylene glycol chain in a site-directed fashion.

Photoinduced Hydroxylation of Organic Halides under Mild Conditions

Presented in this paper is photoinduced hydroxylation of organic halides, providing a mild access to a range of functionalized phenols and aliphatic alcohols. These reactions generally proceed under mild reaction conditions with no need for a photocatalyst or a strong base and show a wide substrate scope as well as excellent functional group tolerance. This work highlights the unique role of NaI that allows a challenging transformation to proceed under mild reaction conditions.