1417441-29-2Relevant academic research and scientific papers
Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds
Benhida, Rachid,Demange, Luc,Dufies, Maeva,Grytsai, Oleksandr,Hagege, Anais,Martial, Sonia,Pagès, Gilles,Penco-Campillo, Manon,Ronco, Cyril,Valiashko, Oksana
, (2020)
Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.
Microwave assisted synthesis and biological activity of n-aryl-n'-nicotinoyl thiourea
Tong, Jian-Ying,Sun, Na-Bo,Wu, Hong-Ke
, p. 5420 - 5422 (2013/07/26)
A series of N-aryl-N'-nicotinoyl thiourea derivatives were synthesized using microwave irradiation. The synthesized compounds were characterized by 1H NMR, IR, MS and elemental analysis. Fungicidal activity of the compounds were evaluated through G. zeae
