141805-86-9

Basic information

• Product Name: 2-Thiazolidinethione, 4-(1-methylethyl)-3-[1-oxo-3-(phenylmethoxy)propyl]-, (R)-
• CAS NO: 141805-86-9
• Molecular Formula: C16H21NO2S2
• Molecular Weight: 323.48
• Mol File: 141805-86-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Thiazolidinethione, 4-(1-methylethyl)-3-[1-oxo-3-(phenylmethoxy)propyl]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolidinethione, 4-(1-methylethyl)-3-[1-oxo-3-(phenylmethoxy)propyl]-, (R)-(141805-86-9)
• EPA Substance Registry System: 2-Thiazolidinethione, 4-(1-methylethyl)-3-[1-oxo-3-(phenylmethoxy)propyl]-, (R)-(141805-86-9)

Safety Data

• Hazardous Substances Data: 141805-86-9(Hazardous Substances Data)

Upstream product

• 4126-60-7 methyl β-benzyloxypropionate 
• 100-51-6 benzyl alcohol 
• 27912-85-2 3-(benzyloxy)propanoic acid 
• 110199-16-1 4(R)-isopropyl-1,3-thiazolidine-2-thione 

Downstream Products

• 141805-88-1 (4R)-3-<(2S,3R)-3-<(tert-Butyldimethylsilyl)oxy>-2-<(benzyloxy)methyl>butanoyl>-4-isopropyl-1,3-thiazolidine-2-thione 
• 141805-89-2 (2S,3R)-3-<(tert-Butyldimethylsilyl)oxy>-2-<(benzyloxy)methyl>-N-(4-methoxyphenyl)butylamide 
• 141805-87-0 (4R)-3-<(2S,3R)-3-Hydroxy-2-<(benzyloxy)methyl>butanoyl>-4-isopropyl-1,3-thiazolidine-2-thione 

Relevant articles and documents

β-Lactams. 3. Asymmetric Total Syntheis of New Non-Natural 1β-Methylcarbapenems Exhibiting Strong Antimicrobial Activities and Stability against Human Renal Dehydropeptidase-I

Asymmetric synthesis of 11, the precursor to chiral (3R,4R)-3-ethyl>-4-acetoxyazetidin-2-one (3) was achieved by utilizing a highly diastereoselective aldol-type reaction of acetaldehyde and the chiral tin(II) enolate of 5.Similar diastereoselective alkylations of chiral and achiral tin(II) enolates 13a-d with chiral 3 were also performed to obtain the desired alkylated azetidin-2-ones (17a-d).Compounds 17a,b were successfully converted to new, non-natural 1β-methylcarbapenems 1a and 1b, which exhibited strong and wide-ranging antimicrobial activities and excellent stability against human renal dehydropeptidase-I.