27912-85-2

Usage

Uses

Used in Chemical Synthesis:
3-(benzyloxy)propanoic acid is used as a reagent for hydroxypropionyl alkylation, a chemical process that involves the introduction of a hydroxypropionic group into a molecule. This alkylation reaction is crucial in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(benzyloxy)propanoic acid is used as an intermediate in the synthesis of drugs. Its unique structure allows for the creation of new drug candidates with potential therapeutic applications.
Used in Research and Development:
3-(benzyloxy)propanoic acid is also utilized in research and development settings, where it serves as a valuable tool for understanding the reactivity and behavior of various chemical groups. This knowledge can be applied to the design and development of new molecules with specific properties and functions.
Used in Material Science:
In the field of material science, 3-(benzyloxy)propanoic acid can be used to modify the properties of polymers and other materials. Its incorporation into these materials can lead to improved characteristics, such as enhanced stability, increased reactivity, or altered physical properties.
Overall, 3-(benzyloxy)propanoic acid is a versatile compound with a wide range of applications across various industries, including pharmaceuticals, chemical synthesis, research and development, and material science. Its unique chemical properties and reactivity make it an essential tool in the development of new compounds and materials with potential applications in various fields.

Upstream product

• 57-57-8 β-Propiolactone 
• 100-51-6 benzyl alcohol 
• 4126-60-7 methyl β-benzyloxypropionate 
• 4799-68-2 3-benzyloxypropan-1-ol 
• 100-39-0 benzyl bromide 
• 127113-02-4 ethyl 3-(benzyloxy)propanoate 
• 19790-60-4 3-Benzyloxypropanal 
• 6328-48-9 3-benzyloxypropionitrile 
• 100-44-7 benzyl chloride 
• 292638-85-8 acrylic acid methyl ester 
• 98689-60-2 5-benzyloxypent-2-yne 
• 106914-54-9 (3,3-Bis-tert-butylperoxy-propoxymethyl)-benzene 

Downstream Products

• 16440-97-4 5,6-Dimethylindan-1-one 
• 4244-66-0 3-benzyloxypropionyl chloride 
• 145122-40-3 5-(3'-Benzyloxy-1'-hydroxypropylidene)-2,2-dimethyl-1,3-dioxan-4,6-dione 
• 141805-86-9 (4R)-3-<3-(Benzyloxy)propanoyl>-4-isopropyl-1,3-thiazolidine-2-thione 
• 19340-79-5 β-Benzyloxy-propionsaeure-benzylamid 
• 329950-05-2 Acetic acid (2S,3R,4R,5S,6R)-2,5-diacetoxy-6-acetoxymethyl-3-(3-benzyloxy-propionylamino)-tetrahydro-pyran-4-yl ester 
• 329791-50-6 methyl 4,6-dideoxy-4-(3-benzyloxypropanamido)-2-O-methyl-α-D-mannopyranoside 
• 257956-62-0 butyl 3-benzyloxypropionoate 
• 940877-21-4 3-benzyloxy-propionic acid (S)-1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-3-chloromethyl-but-3-enyl ester 
• 940876-99-3 3-benzyloxy-propionic acid (R)-3-chloromethyl-1-phenethyl-but-3-enyl ester 
• 940877-01-0 3-benzyloxy-propionic acid (R)-3-iodomethyl-1-phenethyl-but-3-enyl ester 
• 940877-22-5 3-benzyloxy-propionic acid (S)-1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-3-iodomethyl-but-3-enyl ester 
• 372161-02-9 N²-[3-(benzyloxy)propanoyl]-2'-deoxyguanosine 
• 326596-68-3 (3-benzyloxy-1-tert-butylsulfanylpropenyloxy)trimethylsilane 

Relevant academic research and scientific papers

5-HT3 receptor modulator containing heterocyclic nitrogen as well as preparation method and application thereof

The invention provides a 5-HT3 receptor modulator containing heterocyclic nitrogen as well as a preparation method and application thereof, belonging to the field of medicinal chemistry. The 5-HT3 receptor modulator containing heterocyclic nitrogen is a c

TREX1 INHIBITORS AND USES THEREOF

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds for inhibiting three prime repair exonuclease 1 ("TREX1").

Aerobic Oxidation of Diverse Primary Alcohols to Carboxylic Acids with a Heterogeneous Pd-Bi-Te/C (PBT/C) Catalyst

Heterogeneous catalytic aerobic oxidation methods represent a near-ideal approach for the conversion of primary alcohols to carboxylic acids. Here, we report that a heterogeneous catalyst composed of Pd, Bi, and Te supported on activated carbon is highly effective for the oxidation of diverse benzylic and aliphatic primary alcohols, including 5-(hydroxymethyl)furfural (HMF) and substrates bearing heterocycles and other important functional groups. In many cases, the desired carboxylic acid product is obtained in >90% yield. Additionally, the catalyst has been demonstrated in a continuous-flow packed-bed reactor for the oxidation of benzyl alcohol, achieving near-quantitative yield while undergoing over 30 000 turnovers.

PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA

Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer,or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing influenza.

Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor β/δ agonists with neuroprotective activity

We report the pharmacophore of the peroxisome proliferator-activated receptor δ (PPARδ) agonist natural product phosphoiodyn A is the phosphonate core. Synthesis of simplified phosphonate esters 13 and 15 provide structurally novel, highly selective and potent PPARδ agonists (EC50 = 78 and 112 nM, respectively). Further, both compounds demonstrate significant neuroprotective activity in an in vitro cellular model indicating that phosphonates may be an effective novel scaffold for the design of therapeutics for the treatment of neurodegenerative disorders.

Iron-Catalysed Selective Aerobic Oxidation of Alcohols to Carbonyl and Carboxylic Compounds

A method for aerobic alcohol oxidation catalysed by Fe(NO3)3/2,2’-bipyridine/TEMPO has allowed highly selective conversion of primary alcohols into either aldehydes or carboxylic acids in one-step. The oxidation of primary alcohols proceeded selectively to aldehydes, as TEMPO was present in the reaction. Nevertheless, the aldehydes were further oxidized into carboxylic acids as the reaction time was extended. Detailed investigation of the reaction suggested, that the deoxygenation of TEMPO into TMP enabled the auto-oxidation of aldehydes to carboxylic acids, which was initially inhibited in the presence of TEMPO. The procedure was also efficient in oxidation of secondary alcohols when TEMPO was replaced by the less sterically hindered ABNO.

Synthesis of novel benzo[b]pyrazolo[1,5]diazepines

The synthesis and in vitro biological evaluation of two novel benzodiazepine derivatives are described. The compounds were synthesized divergently from the key amino alcohol 5, which was realized using the unusual Weinreb-enamino ketone 10..

Synthesis of polyisoprene terpenoid dendrons and their applications in oligo(phenylene ethynylene)s as "shells"

The novel double-stage convergent synthesis of a new class of polyisoprene terpenoid (PIPTP) dendrons is described. PIPTP dendrons bear a highly branched aliphatic hydrocarbon skeleton and a hydrophilic hydroxy focal point functionality. These dendrons have the specific formula C (5×2G+1-5)H(5×2 G+2-8)O, and each dendritic layer is constructed from an isoprene unit. The key branching steps involve a double alkyl-metal addition to an ester functionality, followed by deoxygenation of the resulting tertiary alcohol by triethylsilane and trifluoroacetic acid, then hydrogenation or hydrogenolysis. The dendrons were also attached to oligo(phenylene ethynylene)s (OPEs) so as to function as protective shells to allow fine tuning of the nanoscopic environment around the OPE moiety, and to exert precise control of the packing density and intermolecular interaction between the OPE cores. Fluorescence quantum yield data reveal that the OPE core is better encapsulated by the PIPTP dendrons than by Frechet dendrons.

A highly convergent approach toward (-)-brevenal

Progress toward a highly convergent, asymmetric synthesis of brevenal is reported. Construction of the AB-ring and E-ring cyclic ether fragments was achieved through asymmetric alkylation/ring-closing metathesis strategies. A Horner-Wadsworth-Emmons olefination was used in a key bond-forming step to couple the advanced cyclic fragments and enable rapid access to the AB-E ring system.

The complete stereochemistry of the enzymatic dehydration of 4-hydroxybutyryl coenzyme A to crotonyl coenzyme A

(Chemical Equation Presented) The stereospecific action of the microbial enzyme 4-hydroxybutyryl-CoA dehydratase on the three prochiral centers of its substrate 4-hydroxybutyryl-CoA can now be described as anti elimination of the 2Re and 3Si hydrogen atoms with retention of configuration during the substitution of the hydroxy group by a hydrogen atom. The results confirm the relationship of the dehydratase to acyl-CoA dehydrogenases and the view that the Fe4S4 cluster acts as a Lewis acid.