14181-05-6

Basic information

• Product Name: ethyl (2,5-dioxopyrrolidin-1-yl)acetate
• CAS NO: 14181-05-6
• Molecular Formula: C₈H₁₁NO₄
• Molecular Weight: 185.1772
• Mol File: 14181-05-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 355.9°C at 760 mmHg
• Flash Point: 169°C
• Density: 1.261g/cm³
• Vapor Pressure: 3.03E-05mmHg at 25°C
• Refractive Index: 1.492
• CAS DataBase Reference: ethyl (2,5-dioxopyrrolidin-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2,5-dioxopyrrolidin-1-yl)acetate(14181-05-6)
• EPA Substance Registry System: ethyl (2,5-dioxopyrrolidin-1-yl)acetate(14181-05-6)

Safety Data

• Hazardous Substances Data: 14181-05-6(Hazardous Substances Data)

Upstream product

• 543-20-4 succinoyl dichloride 
• 459-73-4 GlyOEt*HCl 
• 623-33-6 glycine ethyl ester hydrochloride 
• 71-43-2 benzene 
• 132651-93-5 triphenylphosphine imine ethyl acetate 
• 128-08-5 N-Bromosuccinimide 
• 109-92-2 ethyl vinyl ether 
• 105-39-5 chloroacetic acid ethyl ester 
• 123-56-8 Succinimide 
• 105-36-2 ethyl bromoacetate 
• 108-30-5 succinic acid anhydride 

Downstream Products

• 2955-88-6 1-pyrrolidineethanol 

Relevant articles and documents

A METAL FREE PROCESS FOR THE PREPARATION OF ALPHA-SUBSTITUTED CARBONYL COMPOUNDS FROM ALKENES

The present invention discloses a novel metal free process for the regioselective synthesis of α-substituted carbonyl compounds of formula I from alkene, X is selected from the following compounds (A, B).

Synthesis of cyclic acylated enamino esters from enol lactones, 4-keto amides, and 5-hydroxy lactams

Enol lactones react with an amine to give either a keto amide or a hydroxy lactam under mild conditions. Subsequent dehydration with p-toluenesulfonic acid (PTSA) gives a cyclic acylated enamino ester in good yield. The key prostaglandin analog precursor 18 and the gly-gly dipeptide analogs 26a and 26b were prepared using the reported conditions. Acetylation of the chloro hydroxy lactam 31, prepared from the chloro enol lactones 29, followed by elimination of acetic acid gave the chloro acylated enamino esters 28.

REACTIVITY OF IMINOPHOSPHORANES TOWARDS SOME SYMMETRICAL DICARBONYL DICHLORIDES : SYNTHESES AND MECHANISMS

In situ generated iminophosphoranes 1 react with dicarbonyl dihalides 2a-b and 3a-c to give known or new nitrogen heterocycles.The proposed mechanisms involve elimination of either triphenyl-phosphine oxide or dichlorotriphenylphosphorane depending upon both the iminophosphorane and the dicarbonyl compound.