141815-90-9

Upstream product

• 141799-80-6 N-[6-nitro-2-{3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy}]phenyl-N'-pentylurea 
• 144-55-8 sodium hydrogencarbonate 
• 141815-91-0 1-(3-chloropropyl)-5-methyl-4-phenylimidazole 
• 149376-45-4 phenyl N-<2-<3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy>-6-nitrophenyl>carbamate 
• 148726-33-4 2-<3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy>-6-nitroaniline 
• 603-85-0 2-Amino-3-nitrophenol 

Relevant academic research and scientific papers

Trisubstituted benzene derivatives, composition and methods of treatment

A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. STR1 wherein R1 stands for a lower alkyl group, an amino group which may be substituted, or the like; R2 stands for a group represented by the formula: STR2 (wherein R16 stands for an alkyl group having 1 to 6 carbon atoms, or the like) or the like; R3 stands for a group represented by the formula: --O--(CH2)m --Y (Y stands for an imidazolyl or piperazinyl group, or the like and m is 1 to 6) or the like; R5 stands for a hydrogen atom, a lower alkyl group, or the like; A stands for a group represented by the formula: STR3 (wherein R6 stands for a hydrogen atom, a lower alkyl group, or the like), --N=, or the like; and B stands for a group represented by the formula: STR4 (wherein R4 stands for a hydrogen or the like), --N=, or the like.

Structure-activity relationship of a series of phenylureas linked to 4- phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O- acyltransferase with antiatherosclerotic activity. 2

In our continuing search to find systemically bioavailable ACAT (acyl- CoA:cholesterol O-acyl-transferase) inhibitors with more potent antiatherosclerotic effect than N-[2-(dimethylamino)-6-[3-(5-methyl-4- phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N'-pentyl