141816-08-2 Usage
Chemical class
Imidazole derivatives
Explanation
The compound belongs to a class of chemical compounds that have a 1H-imidazole ring structure.
Explanation
The core structure of the compound is a 1H-imidazole ring, which is a five-membered aromatic ring with one nitrogen atom and one hydrogen atom.
Explanation
A phenyl group (a six-membered aromatic ring) with a chlorine atom at position 3 and a nitro group (-NO2) at position 2 is present in the compound.
Explanation
Another phenyl group is attached to the 1H-imidazole ring at position 4, with a methyl group (-CH3) at position 5 of the phenyl ring.
Explanation
A phenylmethyl group (a benzyl group, -CH2-C6H5) is also attached to the 1H-imidazole ring, further modifying the structure of the compound.
Explanation
The compound's structural features may contribute to its biological activity, making it a potential candidate for pharmaceutical applications.
Explanation
Due to the potential physiological and toxicological effects of the compound, it should be handled and used with caution.
1H-Imidazole ring
Core structure
Propanamine side chain
Attachment to the imidazole ring
3-chloro-2-nitrophenyl group
Chlorine and nitro substituents
5-methyl-4-phenyl group
Methyl and phenyl substituents
Phenylmethyl group
Additional phenyl substituent
Potential pharmaceutical applications
Biological activity
Caution required
Physiological and toxicological effects
Check Digit Verification of cas no
The CAS Registry Mumber 141816-08-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,8,1 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 141816-08:
(8*1)+(7*4)+(6*1)+(5*8)+(4*1)+(3*6)+(2*0)+(1*8)=112
112 % 10 = 2
So 141816-08-2 is a valid CAS Registry Number.
141816-08-2Relevant academic research and scientific papers
Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4- phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity
Kimura,Takase,Hayashi,Tanaka,Ohtsuka,Saeki,Kogushi,Yamada,Fujimori,Saitou,Akasaka
, p. 1630 - 1640 (2007/10/02)
We have discovered N-butyl-N'-[2-(dimethylamino)-6-[3-(4-phenyl-1H- imidazol-1-yl)propoxy]phenyl]urea (4), a novel, potent, and systemically bioavailable inhibitor of ACAT (acylCoA:cholesterol O-acyltransferase). The structure-activity relationships (SARs) of this lead compound 4 were investigated by systematic modification of four regions in the molecule. The compounds prepared in this study were tested for in vitro inhibitory activity toward both aortic and intestinal ACATs, and selected compounds were further tested for in vivo hypocholesterolemic activity. The studies not only resulted in the discovery of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl- 1H-imidazol-1-yl)propoxy]phenyl]-N'-pentylurea (24), with potent activity and moderate plasma level after oral administration, but also revealed the SAR in each modified region. Four compounds (4, 13, 14, 24) were further selected for testing of in vivo antiatherosclerotic activity; 4, 13, and 24 reduced atherosclerotic plaque development to 38-45% of the control value in terms of area, while 14 did not have a significant antiatherosclerotic effect.
