1419221-63-8

Basic information

• Product Name: tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate
• Synonyms: tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate;tert-Butyl N-[4-(difluoromethyl)-2-pyridyl]carbamate
• CAS NO: 1419221-63-8
• Molecular Formula: C11H14F2N2O2
• Molecular Weight: 244.2378664
• Mol File: 1419221-63-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate(1419221-63-8)
• EPA Substance Registry System: tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate(1419221-63-8)

Safety Data

• Hazardous Substances Data: 1419221-63-8(Hazardous Substances Data)

Usage

General Description

Tert-butyl (4-(difluoromethyl)pyridin-2-yl)carbamate, also known as Tiacumicin B, is a chemical compound used in the pharmaceutical industry. It is a carbamate derivative with a tert-butyl group attached to the nitrogen atom and a difluoromethylpyridinyl group attached to the carbon atom. tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate has potential therapeutic applications, particularly as an antibacterial agent, and has shown promise in the treatment of drug-resistant bacterial infections. Its precise mechanism of action is not fully understood, but it is believed to inhibit the growth of bacteria by targeting specific enzymes or cellular processes. Tert-butyl (4-(difluoromethyl)pyridin-2-yl)carbamate is still under investigation for its potential uses in medicine and is not currently approved for clinical use.

Upstream product

• 101066-61-9 2-chloropyridine-4-carbaldehyde 
• 153034-86-7 2-chloro-4-iodopyridine 
• 4248-19-5 tert-butyl carbazate 
• 1204296-03-6 2-chloro-4-(difluoromethyl)pyridine 

Downstream Products

• 1419221-62-7 N-(4-(difluoromethyl)pyridin-2-yl)-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 1620677-32-8 4-bromo-N-(4-(difluoromethyl)pyridin-2-yl)-3-fluorobenzamide 

Relevant articles and documents

Scalable, Economical, and Practical Synthesis of 4-(Difluoromethyl)pyridin-2-amine, a Key Intermediate for Lipid Kinase Inhibitors

A new, scalable, rapid, high yielding, and practical synthesis of 4-(difluoromethyl)pyridin-2-amine provides a key intermediate for the preparation of numerous protein kinase inhibitors and clinical candidates targeting phosphoinositide 3-kinase (PI3K) and the mechanistic target of rapamycin (mTOR) kinase. Starting from 2,2-difluoroacetic anhydride, an efficient five-step and two-pot procedure to prepare 4-(difluoromethyl)pyridin-2-amine (1) has been developed. Noteworthy aspects of this strategy include the avoidance of an amination process using a sealed vessel. Each step of the synthetic route has been optimized, and key intermediates have been isolated and characterized prior to the final two-pot procedure, which has been successfully applied for large-scale production.

BTK INHIBITORS

The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.