141989-80-2

Upstream product

• 352-07-8 N-benzylidene-N'-(4-fluorophenyl)hydrazine 
• 70-11-1 α-bromoacetophenone 
• 100-52-7 benzaldehyde 
• 371-14-2 4-fluorophenylhydrazine 
• 72344-05-9 1-(4-fluorophenyl)-3,5-diphenyl-4,5-dihydro-1H-pyrazole 
• 732306-64-8 bis(4-fluorophenyl)iodonium triflate 
• 1145-01-3 3,5-Diphenylpyrazole 
• 1448602-26-3 (4-fluorophenyl)(4-methoxyphenyl)iodonium p-toluenesulfonate 
• 462-06-6 fluorobenzene 
• 589-87-7 1,4-bromoiodobenzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 591-50-4 iodobenzene 
• 84383-77-7 (4-fluorophenyl)(hydroxy)-λ3-iodaneyl 4-methylbenzenesulfonate 
• 624-31-7 4-tolyl iodide 

Relevant academic research and scientific papers

Visible light mediated metal-free oxidative aromatization of 1,3,5-trisubstituted pyrazolines

The visible light mediated oxidation of 1,3,5-trisubstituted pyrazolines under metal-free conditions was developed. Various substituted pyrazolines were oxidized to pyrazoles by irradiation with visible light/sunlight. A plausible mechanism was proposed f

Radical Addition of Hydrazones by α-Bromo Ketones to Prepare 1,3,5-Trisubstituted Pyrazoles via Visible Light Catalysis

A novel efficient tandem reaction of hydrazones and α-bromo ketones is reported for the preparation of 1,3,5-trisubstituted pyrazoles by visible light catalysis. In this system, the monosubstituted hydrazones show wonderful reaction activity with alkyl radicals, generated from α-bromo ketones. A radical addition followed by intramolecular cyclization affords the important pyrazole skeleton in good to excellent yields. This efficient strategy under mild conditions with wide group tolerance provides a potential approach to the 1,3,5-trisubstituted pyrazoles.

Transition-Metal-Free N-Arylation of Pyrazoles with Diaryliodonium Salts

A new synthetic method was developed for the N-arylation of pyrazoles using diaryliodonium salts. The transformation does not require any transition-metal catalyst and provides the desired N-arylpyrazoles rapidly under mild reaction condition in the presence of aqueous ammonia solution as a mild base without the use of inert atmosphere. The chemoselectivity of unsymmetric diaryliodonium salts was also explored with large number of examples.