141997-14-0Relevant articles and documents
Mechanism and structure-activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase
Dixon, Mark J.,Maurer, Richard I.,Biggi, Cristina,Oyarzabal, Julen,Essex, Jonathan W.,Bradley, Mark
, p. 4513 - 4526 (2007/10/03)
A library of polyamine-peptide conjugates based around some previously identified inhibitors of trypanothione reductase was synthesised by parallel solid-phase chemistry and screened. Kinetic analysis of library members established that subtle structural
Dde - A selective primary amine protecting group: A facile solid phase synthetic approach to polyamine conjugates
Nash, Ian A.,Bycroft, Barrie W.,Chan, Weng C.
, p. 2625 - 2628 (2007/10/03)
The ability of the 2-chlorotrityl chloride resin and Dde to act as selective and orthogonal primary amine protecting groups has been utilised in a novel solid phase synthesis of protected symmetrical polyamines from which philanthotoxin-343 and sFTX-3.3 have been synthesized.