82409-04-9Relevant articles and documents
INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN FOR WHICH THE PI IS FROM 5.8 TO 8.5 AND A CO-POLYAMINO ACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS
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Paragraph 0515, (2021/01/19)
A composition in the form of an injectable aqueous solution, whose pH consists from 6.0 to 8.0, including at least: a basal insulin whose isoelectric point includes from 5.8 to 8.5; a co-polyamino-acid bearing carboxylate charges and hydrophobic radicals Hy, the co-polyamino-acid being constituted of glutamic or aspartic units and said hydrophobic radicals Hy according to the following formula I:
B-Z transition of (dA-T)n duplexes induced by a spermine porphyrin-conjugate via an intermediate DNA conformation
Sasaki, Hideaki,Sasaki, Shigeki
supporting information, p. 9024 - 9026 (2013/09/24)
The spermine conjugate of the cationic porphyrin ligand (1) selectively induced the B-Z transition of the [(dA-T)n]2 sequence at low salt concentrations. The [(dG-C)n]2 sequence was not transformed into the Z-form. The B-Z transition was induced via an intermediate DNA conformation, which was formed by the external binding and formation of an assembly of 1 onto B-DNA.
Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site
Abe, Yukiko,Nakagawa, Osamu,Yamaguchi, Rie,Sasaki, Shigeki
experimental part, p. 3470 - 3479 (2012/08/08)
DNA is continuously damaged by endogenous and exogenous factors such as oxidative stress or DNA alkylating agents. These damaged nucleobases are removed by DNA N-glycosylase and form apurinic/apyrimidinic sites (AP sites) as intermediates in the base exci