142047-97-0

Upstream product

• 3926-62-3 sodium monochloroacetic acid 
• 107-21-1 ethylene glycol 
• 79-11-8 chloroacetic acid 
• 3041-16-5 p-dioxanone 
• 7388-28-5 sodium 2-hydroxyethoxide 

Downstream Products

• 58349-37-4 methyl 2-(2-hydroxyethoxy)acetate 

Relevant academic research and scientific papers

Lactone metabolite common to the carcinogens dioxane, diethylene glycol, and N-nitrosomorpholine: Aqueous chemistry and failure to mediate liver carcinogenesis in the F344 rat

1,4-Dioxan-2-one, 1, was synthesized, and the equilibrium constant between it and the hydrolysis product 2-(2-hydroxyethoxy) acetic acid, 2, was determined as KO = 70 ± 4 in acidic aqueous media, 25 °C, ionic strength 1 M (KCl), and 5% by volume acetonitrile. The carboxylic acid dissociation constant of 2 was determined under the same conditions to be pKa = 3.31 ± 0.02. On the basis of these two determinations, the equilibrium constant between 1 and carboxylic acid anion, 3, and the proton was calculated to be KOA = 0.034 ± 0.002 M. The stability of 1 was determined in the range of pH between 1 and 8.5 in buffered aqueous solutions under the conditions above by UV spectrophotometric methods and exhibited simple first order kinetics of decay. On the basis of buffer dilution plots, the values of ko, the rate constant for solvent mediated decomposition, were determined. The plot of log ko against pH is consistent with a three term rate law for solvolysis with a hydrogen ion catalyzed rate constant kH+ = 1.1 (±0.1) M-1 min-1, a water catalyzed rate constant, kw = 9.9 (±0.5) × 10-4 min-1, and a hydroxide ion catalyzed rate constant, kOH = 4.1 (±0.3) × 10 4 M-1 min-1. The t1/2 for decay at pH 7.0, at 25 °C, is ～2 h. Treatment of F344 rats with aflatoxin B 1 (AFB1) (positive control) elicited the expected preneoplastic foci in the livers of each rat tested, while subsequent administration of 1 (a total of 1.32 g over 12 weeks) failed to statistically increase focal number or focal volume percent. In 8 rats administered 1 (1.32 g, 12 weeks) alone, no increase above background foci was detected. This study does not support compound 1 as a common carcinogen.

New Monodisperse Magnetic Polymer Microspheres Biofunctionalized for Enzyme Catalysis and Bioaffinity Separations

Magnetic macroporous PGMA and PHEMA microspheres containing carboxyl groups are synthesized by multi-step swelling and polymerization followed by precipitation of iron oxide inside the pores. The microspheres are characterized by SEM, IR spectroscopy, AAS

PROCESS FOR THE PREPARATION OF 2-CHLOROETHOXY-ACETIC ACID-N,N-DIMETHYLAMIDE

According to the present invention, 2-chloroethoxy-acetic acid-N,N-dimethylamide of the Formula (I) is prepared by reacting 2-hydroxyethoxy-acetic acid-N,N-dimethylamide of the Formula (II) in a solvent optionally in the presence of a catalyst with thionyl chloride and removing the solvent by distillation.

Purified salt of beta-hydroxyethoxy acetic acid, purified 2-p-dioxanone, and manufacturing method therefor

A purified salt of β-hydroxyethoxy acetic acid of formula (1) having a fusion peak-top temperature detected by differential scanning calorimetry (DSC) and a purified 2-p-dioxanone of formula (2) derived from the purified salt of β-hydroxyethoxy acetic acid of formula (1). (wherein in formula (1), n=1-2 , and if n=1, M is Na and/or K, and, if n=2, M is Ca and/or Mg.)