142071-76-9Relevant academic research and scientific papers
Design, synthesis and biological evaluation of nitrofuran-1,3,4-oxadiazole hybrids as new antitubercular agents
Wang, Apeng,Xu, Shijie,Chai, Yun,Xia, Guimin,Wang, Bin,Lv, Kai,Wang, Dan,Qin, Xiaoyu,Jiang, Bin,Wu, Wenhao,Liu, Mingliang,Lu, Yu
, (2021/12/02)
Three series of novel nitrofuran-1,3,4-oxadiazole hybrids were designed and synthesized as new anti-TB agents. The structure activity relationship study indicated that the linkers and the substituents on the oxadiazole moiety greatly influence the activity, and the substituted benzenes are more favoured than the cycloalkyl or heterocyclic groups. Besides, the optimal compound in series 2 was active against both MTB H37Rv strain and MDR-MTB 16883 clinical isolate and also displayed low cytotoxicity, low inhibition of hERG and good oral PK, indicating its promising potential to be a lead for further structural modifications.
1,4,5,6-TETRAHYDRO-1,2,4-TRIAZIN-6-ONES AND 3-AMINO-1-IMIDAZOLIN-4-ONES FROM 2-AMINOACYLHYDRAZINES
Lobanov, P. S.,Grebelkin, A. L.,Zaitsev, D. I.,Gindin, V. A.,Potekhin, A. A.
, p. 1116 - 1119 (2007/10/02)
The 2-aminoacylhydrazines form 1,4,5,6-tetrahydro-1,2,4-triazin-6-ones with orthoesters and iminoesters.Benzylidene and isopropylidene derivatives of the 2-aminoacylhydrazines give the corresponding derivatives of 3-amino-1-imidazolin-4-ones with the same
