14379-80-7

Basic information

• Product Name: 2-aminoacetohydrazide (non-preferred name)
• Synonyms: 2-Aminoacetohydrazide (non-preferred name)
• CAS NO: 14379-80-7
• Molecular Formula: C₂H₇N₃O
• Molecular Weight: 89.0965
• Mol File: 14379-80-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 340.2°C at 760 mmHg
• Flash Point: 159.6°C
• Density: 1.19g/cm³
• Vapor Pressure: 8.72E-05mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: 2-aminoacetohydrazide (non-preferred name)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aminoacetohydrazide (non-preferred name)(14379-80-7)
• EPA Substance Registry System: 2-aminoacetohydrazide (non-preferred name)(14379-80-7)

Safety Data

• Hazardous Substances Data: 14379-80-7(Hazardous Substances Data)

Usage

Physical properties

white crystalline solid, soluble in water, melting point of 174-176 degrees Celsius

Uses

synthesis of pharmaceuticals, dyes, and agrochemicals; reagent for detection of aldehydes and ketones

Potential properties

antimicrobial and antitumor properties

Commonly known as

glycine hydrazide

Upstream product

• 459-73-4 GlyOEt*HCl 
• 7803-57-8 hydrazine hydrate 
• 869-19-2 Glycyl-L-leucine 
• 302-01-2 hydrazine 
• 616-34-2 methoxycarbonylmethylamine 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 623-33-6 glycine ethyl ester hydrochloride 

Downstream Products

• 82507-66-2 1,4,5-trihydro-3-pheny<1,2,4>triazin-6(2H)-one 
• 168144-56-7 C₂₀H₂₅N₅OS₂ 
• 168144-55-6 C₁₆H₁₅Br₂N₅OS₂ 
• 14132-84-4 4?phenyl?3?(phenylamino)?1H?1,2,4?triazole?5(4H)?thione 
• 56-40-6 glycine 
• 168144-54-5 C₁₈H₂₁N₅O₃S₂ 
• 168144-52-3 C₁₆H₁₇N₅OS₂ 
• 168144-53-4 C₁₈H₂₁N₅OS₂ 
• 142071-78-1 3-isopropylidenamino-2,2-dimethylimidazolidin-4-one 
• 142071-76-9 4-methoxybenzaldehyde 2-aminoacetylhydrazone 
• 63221-10-3 N-(N-benzoyl-glycyl)-glycine hydrazide 

Relevant articles and documents

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In situ deprotection and incorporation of unnatural amino acids during cell-free protein synthesis

The S30 extract from E. coli BL21 Star (DE3) used for cell-free protein synthesis removes a wide range of α-amino acid protecting groups by cleaving α-carboxyl hydrazides; methyl, benzyl, tert-butyl, and adamantyl esters; tert-butyl and adamantyl carboxamides; α-amino form-, acet-, trifluoroacet-, and benzamides and sidechain hydrazides and esters. The free amino acids are produced and incorporated into a protein under standard conditions. This approach allows the deprotection of amino acids to be carried out in situ to avoid separate processing steps. The advantages of this approach are demonstrated by the efficient incorporation of the chemically intractable (S)-4-fluoroleucine, (S)-4,5- dehydroleucine, and (2S,3R)-4-chlorovaline into a protein through the direct use of their respective precursors, namely, (S)-4-fluoroleucine hydrazide, (S)-4,5-dehydroleucine hydrazide, and (2S,3R)-4-chlorovaline methyl ester. These results also show that the fluoroand dehydroleucine and the chlorovaline are incorporated into a protein by the normal biosynthetic machinery as substitutes for leucine and isoleucine, respectively. Copyright

Glycine hydrazide as a bifunctional reagent for the synthesis of antigens with steroids as the immunodeterminant groups

The suitability of glycine hydrazide as a link between steroids and carrier proteins in the synthesis of antigens was examined. Testosterone was used as hapten; bovine serum albumin as carrier protein. The reaction described here of testosterone with glycine hydrazide to form testosterone glycylhydrazone acetate took place under mild conditions and the yield was nearly quantitative. Rabbits immunized with the new antigen developed specific antibodies against testosterone.