142102-83-8

Basic information

• Product Name: 1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-3-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 142102-83-8
• Molecular Formula: C₂₆H₄₅N₃O₈SSi₂
• Molecular Weight: 615.8868
• Mol File: 142102-83-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 623.9°C at 760 mmHg
• Flash Point: 331.1°C
• Density: 1.21g/cm³
• Vapor Pressure: 1.75E-15mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-3-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-3-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione(142102-83-8)
• EPA Substance Registry System: 1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-3-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione(142102-83-8)

Safety Data

• Hazardous Substances Data: 142102-83-8(Hazardous Substances Data)

Usage

Chemical structure

A complex chemical compound with a long and specific structure.

Core

Contains a pyrimidine core.

Amino group

A nitrogen-containing group that can form hydrogen bonds and coordinate with metal ions.

tert-butyl and dimethylsilyl oxy groups

Bulky, hydrophobic groups that can protect the molecule from degradation and increase its lipophilicity.

Prop-2-en-1-yl group

An alkenyl group that can participate in various chemical reactions and may influence the compound's reactivity and stability.

Stereochemistry

The compound has a specific stereochemistry, with the 6R, 8R, and 9R configurations, which can affect its biological activity and interactions with target molecules.

Medicinal applications

Due to its complex structure, the compound has potential medicinal applications and could interact with biological systems in various ways.

Further study

The compound would likely require additional research and testing to fully understand its potential uses and effects.
Please note that this list is based on the information provided and may not be exhaustive. Further research and analysis would be necessary to fully characterize the compound and its properties.

Upstream product

• 142102-72-5 1-(2'-O-acetyl-5'-O-benzoyl-3'-C-cyano-3'-O-mesyl-β-D-ribofuranosyl)uracil 
• 151215-43-9 1,2-di-O-acetyl-5-O-benzoyl-3-C-cyano-3-O-mesyl-D-ribofuranose 
• 141684-50-6 1-((5S,6R,8R,9R)-4-Amino-9-hydroxy-6-hydroxymethyl-2,2-dioxo-1,7-dioxa-2λ⁶-thia-spiro[4.4]non-3-en-8-yl)-1H-pyrimidine-2,4-dione 
• 142131-02-0 5-O-benzoyl-3-C-cyano-1,2-O-isopropylidene-3-O-mesyl-α-D-ribofuranose 
• 250588-64-8 Benzoic acid (3aR,5R,6R,6aR)-6-cyano-6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester 
• 6698-46-0 5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose 
• 141845-83-2 {1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]uracil}-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) 
• 106-95-6 allyl bromide 

Relevant articles and documents

TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1- [2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3'-spiro-5''-(4''- amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides

Several analogues of a new lead for anti-HIV-1 agents [1-[2',5'-bis-O- (tert-butyldimethylsilyl)-β-D-ribofuranosyl]-thymine]-3'-spiro-5''-(4''- amino-1'',2''-oxathiole 2'',2''-dioxide) (TSAO) modified at positions N-3, O- 4 and C-5 of the thymine moiety,