142102-72-5

Upstream product

• 151215-43-9 1,2-di-O-acetyl-5-O-benzoyl-3-C-cyano-3-O-mesyl-D-ribofuranose 
• 66-22-8 uracil 
• 10457-14-4 O,O'-bis-(trimethylsilyl)uracil 
• 142131-02-0 5-O-benzoyl-3-C-cyano-1,2-O-isopropylidene-3-O-mesyl-α-D-ribofuranose 
• 250588-64-8 Benzoic acid (3aR,5R,6R,6aR)-6-cyano-6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester 
• 6698-46-0 5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose 

Downstream Products

• 141684-50-6 1-((5S,6R,8R,9R)-4-Amino-9-hydroxy-6-hydroxymethyl-2,2-dioxo-1,7-dioxa-2λ⁶-thia-spiro[4.4]non-3-en-8-yl)-1H-pyrimidine-2,4-dione 
• 142102-78-1 <1-<2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>cytosine>-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) 
• 141845-83-2 {1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]uracil}-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) 
• 142102-83-8 <1-<2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>-3-N-allyluracil>-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) 

Relevant academic research and scientific papers

TSAO derivatives: Highly specific inhibitors of human immunodeficiency virus type-1 (HIV-1) replication

TSAO derivatives represent a unique class of nucleosides that are specifically targeted at HIV-1 RT. This overview is focussed on the chemical synthesis, the conformational studies, the antiviral and metabolic properties of TSAO derivatives, as well as th

TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1- [2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3'-spiro-5''-(4''- amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides

Several analogues of a new lead for anti-HIV-1 agents [1-[2',5'-bis-O- (tert-butyldimethylsilyl)-β-D-ribofuranosyl]-thymine]-3'-spiro-5''-(4''- amino-1'',2''-oxathiole 2'',2''-dioxide) (TSAO) modified at positions N-3, O- 4 and C-5 of the thymine moiety,