142183-78-6

Upstream product

• 71-43-2 benzene 
• 102-25-0 1,3,5-triethylbenzene 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 181058-10-6 1,3,5-tris(2'-aminoethyl)-2,4,6-triethylbenzene 
• 1027638-66-9 (3-(2-pyridyl)pyrazolylmethyl)3C₆(ethyl)3 
• 1027638-72-7 C₄₈H₄₈N₆ 
• 149525-65-5 1,3,5-triethyl-2,4,6-tris(aminomethyl)benzene 
• 223737-62-0 N,N,N',N',N'',N''-hexa[(2-pyridyl)methyl]-1,3,5-tris(aminomethyl)-2,4,6-triethylbenzene 
• 181058-09-3 1,3,5-tris(cyanomethyl)-2,4,6-triethylbenzene 
• 350835-93-7 1,3,5-tris(hydroxymethyl)-2,4,6-triethylbenzene 
• 190779-62-5 1,3,5-tris(azidomethyl)-2,4,6-triethylbenzene 

Relevant academic research and scientific papers

HEXASUBSTITUTED BENZENES, SURFACES MODIFIED THEREWITH, AND ASSOCIATED METHODS

Phenyl rings provide a robust scaffold for molecular design, given the limited number of ring carbon atoms and the fixed geometry in between. However, it can be difficult to form highly substituted phenyl rings suitable for covalent attachment of multiple

Preparation of 1,3,5-tris(aminomethyl)-2,4,6-triethylbenzene from two versatile 1,3,5-tri(halosubstituted) 2,4,6-triethylbenzene derivatives

The use of 1,3,5-tris(aminomethyl)-2,4,6-triethylbenzene and the intermediates 1,3,5-tris(halomethyl)-2,4,6-triethylbenzene (halo = bromo and chloro) compounds, have been utilized as scaffolds for many molecular receptors. We report here for the first time a detailed practical synthetic procedure, starting from benzene, and in four straightforward steps, to prepare 1,3,5-tris(aminomethyl)-2,4,6-triethylbenzene, a very versatile molecular scaffold. The added advantage is the limited chromatography in the purification procedure. Georg Thieme Verlag Stuttgart.

Control of functional group proximity and direction by conformational networks: Synthesis and stereodynamics of persubstituted arenes

The cooperative nonbonded interactions present in hexaethylbenzene result in an arrangement of alkyl groups such that the 1,3,5 and 2,4,6 substituents point to opposite faces of the benzene ring. Correspondingly, derivatives of hexaethylbenzene have their functional groups convergent (meta as in 1,3,5-trisubstituted-2,4,6-triethylbenzene) or divergent (ortho, para as in 1,2-disubstituted-3,4,5,6-tetraethylbenzenes or 1,4-disubstituted-2,3,5,6-tetraethylbenzenes) due to this cooperative conformational network. To illustrate this structural feature and probe its dynamics, 1,4-di-X-2,3,5,6-tetraethylbenzenes have been synthesized. The dynamic stereochemistry of the disubstituted compounds has been studied by variable temperature 1H NMR spectroscopy. Using the same strategy, the 1,3,5-tris(CH2Y)-2,4,6-triethylbenzenes have also been prepared. The steric bulk of the substituent in the disubstituted compounds has been found to influence the barrier height. The trends found are applicable for the use of these compounds as angular building blocks for the design of ligands, polymers, and supramolecular architectures.