14229-93-7Relevant articles and documents
Four-component thiazole formation from simple chemicals under metal-free conditions
Jiang, Jingjing,Huang, Huawen,Deng, Guo-Jun
supporting information, p. 986 - 990 (2019/03/12)
Multi-component reactions for the synthesis of polysubstituted thiazoles from simple chemicals are described. Under metal-free reaction conditions, cheap and easily available ketones, aldehydes, ammonium salt, and elemental sulfur are self-assembled to provide entries to three thiazoles in moderate to good yield with a range of functionalities tolerated.
One pot synthesis of substituted imidazopyridines and thiazoles from styrenes in water assisted by NBS
Shinde, Mahesh H.,Kshirsagar, Umesh A.
, p. 1455 - 1458 (2016/04/04)
Heating of commercially available styrenes with NBS in water followed by reaction with 2-aminopyridines or thioamides afforded important heterocyclic scaffolds in a one pot procedure. The reaction proceeds via co-oxidant free, in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant followed by trapping with suitable nucleophiles to provide imidazopyridines and thiazoles.