142338-01-0

Usage

Uses

Used in Pharmaceutical Industry:
Benzamide, N-benzoyl-N,2-dimethylis used as a precursor for the preparation of various pharmaceuticals. It plays a crucial role in the synthesis of drugs, contributing to the development of new medications.
Used in Organic Chemistry Research:
Benzamide, N-benzoyl-N,2-dimethylis used as a reagent in organic synthesis for the formation of amides. It is an essential component in the study and development of new organic compounds and their potential applications.

Upstream product

• 2170-09-4 N,2-dimethylbenzamide 
• 98-88-4 benzoyl chloride 
• 108-88-3 toluene 
• 188674-85-3 2-(Bis-trimethylsilanyl-methyl)-N-methyl-benzamide 
• 145104-23-0 ortho-trimethylsilylmethyl-N-methylbenzamide 
• 188674-64-8 N-[2-(Bis-trimethylsilanyl-methyl)-benzoyl]-N-methyl-benzamide 

Downstream Products

• 142386-65-0 [2-(Benzoyl-methyl-aminocarbonyl)-benzyl]-triphenyl-phosphonium; bromide 
• 34497-10-4 2-methyl-3-phenylisoquinolin-1(2H)-one 
• 142338-02-1 N-(2-Bromomethyl-benzoyl)-N-methyl-benzamide 

Relevant academic research and scientific papers

I2/Aqueous TBHP-Catalyzed Coupling of Amides with Methylarenes/Aldehydes/Alcohols: Metal-Free Synthesis of Imides

We present a metal-free method for the synthesis of imides by the direct coupling of NH-amides with methylarenes under iodine/aqueous TBHP conditions. The optimized conditions worked very well with benzaldehydes and benzyl alcohol and furnished the corresponding imides in good to excellent yields. A series of control and radical scavenger experiments were also performed, which suggested the involvement of radical pathways. The labeling experiment in the presence of 18O-labeled H2O suggested water as a source of oxygen in the imides.

Fluoride ion-induced cyclization of o-[bis(trimethylsilyl)methyl]-N-acylbenzamide derivatives. New efficient synthesis of 2,3-differentially substituted 1(2H)-isoquinolones

A wide variety of 2-alkyl-3-alkyl, -3-aryl and -3-heteroaryl-1(2H)-isoquinolones have been obtained by fluoride ion-induced intramolecular alkenation of o-[bis(trimethylsilyl)methyl]-N-acylbenzamide derivatives.

A NEW SYNTHETIC ROUTE TO 2-METHYL-3-(ARYL OR ALKYL)-1-OXO-1,2-DIHYDROISOQUINOLINES via AN INTRAMOLECULAR WITTIG REACTION

2-Methyl-3-(aryl or alkyl)-1-oxo-1,2-dihydroisoquinolines 6a-g have been prepared via an intramolecular Wittig olefination reaction from the N-acyl-N-methyl-o-triphenylphosphoniobenzamide bromides 5a-g.