1424-76-6

Upstream product

• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 33921-62-9 2-Methoxy-phenylmagnesium-jodid 
• 860542-70-7 3-acetoxy-1-acetyl-3-(2-methoxy-phenyl)-indolin-2-one 
• 7732-18-5 water 
• 7722-84-1 dihydrogen peroxide 
• 1885-29-6 anthranilic acid nitrile 
• 578-57-4 2-bromoanisole 
• 133776-41-7 anthranilic acid N-methoxy-N-methylamide 
• 529-28-2 4-iodoanisol 

Downstream Products

• 113113-81-8 N-[2-(2-methoxy-benzoyl)-phenyl]-phthalimide 
• 13134-93-5 2-amino-2'-hydroxybenzophenone 
• 34192-74-0 2-(o-Methoxybenzyl)-anilin 
• 6344-60-1 1-hydroxy-9H-fluoren-9-one 
• 1446317-50-5 (2-iodophenyl)(2'-methoxyphenyl)methanone 
• 1609487-73-1 2,2,2-trifluoro-N-(2-(1-hydroxy-1-(2-methoxyphenyl)prop-2-yn-1-yl)phenyl)acetamide 
• 1609487-57-1 N-tert-butyl-2-[3-(2-methoxyphenyl)-1H-indol-2-yl]acetamide 
• 1609487-58-2 2-[3-(2-methoxyphenyl)-1H-indol-2-yl]-N-(2,4,4-trimethylpentan-2-yl)acetamide 
• 33334-26-8 N-(2-(2-methoxybenzoyl)phenyl)acetamide 
• 1300088-80-5 benzyl (6-(2-methoxyphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate 

Relevant academic research and scientific papers

Asymmetric Transfer Hydrogenation of o-Hydroxyphenyl Ketones: Utilizing Directing Effects That Optimize the Asymmetric Synthesis of Challenging Alcohols

A systematic range of o-hydroxyphenyl ketones were reduced under asymmetric transfer hydrogenation conditions using the C3-tethered catalyst 2. Two directing effects, i.e., an o-hydroxyphenyl coupled to a bulky aromatic on the opposite side of the ketone substrate, combine in a matched manner to deliver reduction products with very high enantiomeric excess.

NH2-directed C-H alkenylation of 2-vinylanilines with vinylbenziodoxolones

The first directing-group-mediated C-H alkenylation with alkenyl-λ3-iodanes as electrophilic alkene-transfer reagents has been developed. The application of free aromatic amines as challenging but synthetically valuable directing groups in combination with an IrIII catalyst enabled the synthesis of highly desirable 1, 3- dienes in excellent yields of up to 98% with high to perfect (Z, E) stereoselectivity. A broad substrate scope and further synthetic modifications are demonstrated.

Cascade Amination/Cyclization/Aromatization Process for the Rapid Construction of [2,3-c]Dihydrocarbazoles and [2,3-c]Carbazoles

An intramolecular cascade amination/cyclization/aromatization reaction of functionalized alkylidenecyclopropanes has been developed in the presence of silver acetate, affording a variety of [2,3-c]dihydrocarbazoles and [2,3-c]carbazoles in moderate to excellent yields. The mechanistic investigations revealed that this cascade reaction proceeds through a radical initiated process. Moreover, further transformations for the synthesis of eustifoline-D and an OLED exhibit a potential synthetic utility of this method.

Direct Electrophilic C?H Alkynylation of Unprotected 2-Vinylanilines

Unprotected aromatic amines can be used as directing groups in metal-catalyzed C?H alkynylations of alkenes. By using low amounts of an IrIIIcatalyst in combination with alkynylbenziodoxolones as electrophilic alkyne-transfer reagents, highly desirable 1,3-enynes were isolated in excellent yields of up to 98 % with Z stereoselectivity. A broad substrate scope as well as the high synthetic utility of the 1,3-enynes render this new method an efficient approach for the synthesis of five- and six-membered heterocycles. Further derivatizations of the 1,3-enynes to highly substituted quinolines through AuI- and N-bromosuccinimide-mediated exo-dig cyclizations were demonstrated.