133776-41-7

Basic information

• Product Name: Benzamide, 2-amino-N-methoxy-N-methyl-
• CAS NO: 133776-41-7
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.206
• Mol File: 133776-41-7.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-amino-N-methoxy-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-amino-N-methoxy-N-methyl-(133776-41-7)
• EPA Substance Registry System: Benzamide, 2-amino-N-methoxy-N-methyl-(133776-41-7)

Safety Data

• Hazardous Substances Data: 133776-41-7(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 118-92-3 anthranilic acid 

Downstream Products

• 1581-13-1 2-amino-2'-fluorobenzophenone 
• 2894-51-1 2-amino-4'-chlorobenzophenone 
• 133776-44-0 (2-aminophenyl)(3-benzyloxyphenyl)methanone 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 133776-50-8 4-(2-aminobenzoyl)benzonitrile 
• 133776-51-9 3'-(tert-butoxycarbonyl)-2-aminobenzophenone 
• 133776-43-9 2'-(benzyloxy)-2-aminobenzophenone 
• 3800-06-4 2-amino-4'-fluorobenzophenone 
• 38824-11-2 (2-aminophenyl)-(3-methoxyphenyl)methanone 
• 758686-14-5 N-[2-(furan-2-carbonyl)-phenyl]-4-methyl-benzenesulfonamide 
• 249765-58-0 [2-(methoxy(methyl)carbamoyl)phenyl]carbamic acid tert-butyl ester 

Relevant articles and documents

Iridium-Catalyzed C-H Amination of Weinreb Amides: A Facile Pathway toward Anilines and Quinazolin-2,4-diones

C-H amination of arenes directed by weakly coordinating Weinreb amides has been achieved with an iridium catalyst and 2,2,2-trichloroethoxycarbonyl (Troc) azide as an aminating agent, providing a robust method of producing synthetic useful ortho-TrocNH aryl Weinreb amides. Taking advantage of the reactivity of Weinreb amide and Troc groups in the amination products, selective hydrolysis was achieved as an attractive process for the synthesis of ortho-NH2 aryl Weinreb amides, which are the building blocks useful in the synthesis of bioactive compounds, and cascade aminocyclization with primary amines was successful and provided an efficient pathway for the construction of quinazolin-2,4-diones, which are present in various alkaloids and natural products.

Novel transformation of aryl 2-iodophenyl ketones into 1,3-diarylisoquinolines with (TMS)2NH, styrenes, NIS, and tBuOK

Treatment of aryl 2-iodophenyl ketones with TMS2NH in the presence of Sc(OTf)3 at warming conditions, followed by the reaction with styrenes and NIS gave N-(1-aryl-2-iodoethyl) aryl 2-iodophenyl ketimines. Further treatment of N-(1-aryl-2-iodoethyl) aryl 2-iodophenyl ketimines with tBuOK in the presence of 1,10-phenanthroline at 120 °C generated 1,3-diarylisoquinolines in moderate yields through SET from tBuOK onto the iodophenyl group to form aryl radicals, their 6-endo-trig cyclization onto the vinyl groups, and aromatization of the cyclized intermediates. The present method is a novel approach for the preparation of the isoquinoline core via two steps from aryl 2-iodophenyl ketones.

Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes

In this paper, we revealed a metal-free and visible light photoinduced method for the rapid construction of spirobi[indene] skeletons, providing a simple and efficient way for easy access to spirobi[indene] scaffolds under mild conditions along with a broad substrate scope and good functional group tolerance.