1424-84-6

Upstream product

• 3230-65-7 3,4-dihydroisoquinoline 
• 1071-46-1 hydrogen ethyl malonate 
• 622-24-2 2-phenylethyl chloride 
• 64-04-0 phenethylamine 
• 140-88-5 ethyl acrylate 
• 105-56-6 ethyl 2-cyanoacetate 
• 4041-77-4 ethyl 3,4-dihydroisoquinoline-1-acetate 
• 22901-09-3 2-(2-bromoethyl)benzaldehyde 

Downstream Products

• 1139908-70-5 C₁₅H₂₁NO₂ 
• 1139908-71-6 (R)-(1,2,3,4-Tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester 
• 288839-72-5 (S)-(1,2,3,4-Tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester 
• 734534-01-1 2-(2-iodobenzoyl)-1-[3-(trimethylsilyl)prop-2-ynyl]-3,4-dihydro-1H-isoquinoline 
• 70094-63-2 1,2,3,4,4a,6,7,13-octahydroisoquino<1,2-f>pyrido<2,1-b>pyrimidin-13-one 
• 70094-62-1 1,2,3,4,6,7,11b,12-octahydro-13H-isoquino<2,1-a><1,8>naphthylidin-13-one 
• 74414-16-7 1-(1,5-diaza-2,6-dioxocyclodecanyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Method for establishing tetrahydroisoquinoline compound

The invention discloses a compound which has a structural formula of a formula I shown in the descriptiondescription, and a preparation method of the compound. According to the method, an amino oriented phenylethylamine o-position C(sp)-H bond alkenylation cyclization reaction is implemented, and then a method for efficiently synthesizing the tetrahydroisoquinoline compound is obtained.

Palladium-Catalyzed C(sp2)-H Olefination of Free Primary and Secondary 2-Phenylethylamines: Access to Tetrahydroisoquinolines

A rapid construction of THIQs by a Pd(II)-catalyzed C(sp2)-H olefination of free primary and secondary 2-phenylethylamines with high step- and atom-economy was reported. Notably, no substituent was required at the α-position to the amino group of the 2-phenylethylamines. The substrate scope was broad, and the reaction could also be applied to generate THIQs from the biologically active molecules such as the drug molecule baclofen and phenylalanine ester.

Eight-membered palladacycles derived from the insertion of olefins into the Pd-C bond of ortho-palladated pharmaceuticals phenethylamine and phentermine. Synthesis of stable heck-type intermediates containing accessible β-hydrogens and its use in the synt

The ortho-metalated complexes derived from phenethylamine and phentermine, [Pd(C,N-C6H4CH2CR2NH 2-2)(μ-X)]2 (R = H, X = Br (A); R = Me, X = Cl (B)), react with olefins giving (1) the produc

Tandem SN2-Michael Reactions for the Preparation of Simple Five- and Six-Membered-Ring Nitrogen and Sulfur Heterocycles

A one-pot tandem SN2-Michael addition sequence has been developed for the preparation of five-membered- and six-membered-ring nitrogen and sulfur heterocycles from 6- or 7-halo-2-alkenoate esters.Nitrogen-containing rings are prepared by reaction of the ω-halo-2-alkenoate ester with a primary amine in the presence of triethylamine.The sulfur analogues are generated by thiourea displacement of the halide followed by base hydrolysis of the isothiouronium salt.Yields are routinely in the 60-80percent range.Experiments are described which elucidate the chronology of the reaction sequences.Ring size and steric hindrance to the initial substitution reaction appear to be the only limitations of the procedure.

The Reaction of 3,4-Dihydroisoquinolines With Malonic Acid and Its Derivatives

The reaction of various 3,4-dihydroisoquinolines with malonic acid gives the corresponding 1,2,3,4-tetrahydro-1-isoquinolineacetic acids in good yield, while the reaction with cyanoacetic acid and malonic acid half ethyl ester affords 1,2,3,4-tetrahydro-1

Studies on Quinoline and Isoquinoline Derivatives. VII. Addition Reactions of Acetic Anhydride and Active Methylene Compounds to the Carbon-Nitrogen Double Bond of the Isoquinoline Ring

Acetic anhydride reacted with isoquinoline (IV) itself under reflux to give an addition product, whereas quinoline did not react with acetic anhydride under the same conditions.The structure of the product was determined to be 2-acetyl-1,2-dihydroisoquino