1424328-56-2

Upstream product

• 1310693-13-0 6-chloro-N-(2-fluoro-4-(methylsulfonyl)phenyl)-5-nitropyrimidin-4-amine 
• 143557-91-9 (1R,3S,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 76180-33-1 [2-fluoro-4-(methylthio)phenyl]amine 
• 832755-13-2 2-fluoro-4-methanesulfonylaniline 

Relevant academic research and scientific papers

Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119 agonists

A series of GPR119 agonists based on a 5-nitropyrimidine scaffold bearing endo-azabicyclic substituents were synthesized and evaluated for their GPR119 agonistic activities. Most compounds exhibited much stronger EC50values than that of oleoyle

Synthesis and biological evaluation of 5-nitropyrimidine analogs with azabicyclic substituents as GPR119 agonists

5-Nitropyrimidine analogs substituted with conformationally restricted azabicyclic amines and alcohols were prepared and evaluated their agonistic activity against human GPR119. The analogs bearing endo-azabicyclic amines and alcohols (7, 8, 11, and 12) e