1425606-06-9Relevant articles and documents
Polysubstituted nitrogen-containing heteroaromatic compound, and preparation method and application thereof
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Paragraph 0228-0235; 0301-0306, (2019/10/01)
The present invention relates to a preparation method of a polysubstituted nitrogen-containing heteroaromatic compound. The polysubstituted nitrogen-containing heteroaromatic compound has a structurerepresented by general formula (I) or (II). The method c
Rh-Catalyzed Reaction of Vinyl Azides with Isonitriles and Alkynes/Benzynes
Li, Zongyang,Huo, Tongyu,Li, Li,Feng, Shuo,Wang, Qian,Zhang, Zhen,Pang, Sen,Zhang, Zhiyuan,Wang, Peng,Zhang, Zhenhua
, p. 7762 - 7766 (2019/01/04)
In contrast to well-known transformations of vinyl azides via azirine intermediates or initiating at the alkene moiety, herein we report a Rh(I)-catalyzed coupling reaction of vinyl azides with isonitriles at the azide moiety to form active vinyl carbodiimide intermediates and following tandem cyclization with unsaturated compounds, such as alkynes and benzynes, to give different classes of azaheterocycles. Mechanistically, controlled experiments and DFT calculations disclose that Rh-nitrene is the vital species in the first coupling step, and the Rh(I) catalyst can also play an important role in the cyclization step of alkynes.
Synthesis of 1-aminoisoquinolines by gold(III)-mediated domino reactions from 2-alkynylbenzamides and ammonium acetate
Long, Yuhua,She, Zhigang,Liu, Xiaochen,Chen, Yu
, p. 2579 - 2588 (2013/04/24)
A facile synthetic route toward pharmaceutically interesting 1-aminoisoquinoline derivatives by gold(III)-mediated domino reactions is described. This synthetic protocol starts from readily available 2-alkynylbenzamides and ammonium acetate and takes plac
