142592-46-9Relevant academic research and scientific papers
Rationally Designed Chiral Synthons Enabling Asymmetric Z- and E-Selective Vinylogous Aldol Reactions of Aldehydes
Padarti, Akhil,Han, Hyunsoo
supporting information, p. 1448 - 1452 (2018/03/09)
In a conceptually different approach, highly stereoselective 2-oxonia-Cope rearrangement reactions between rationally designed nonracemic vinylogous aldolation synthons and aldehydes are described to provide δ-hydroxy-α,β-unsaturated esters with excellent
Simple stereoselective synthesis of unsaturated lactone intermediates and their conversion into natural dihydropyranones and their enantiomers#
Shinde, Digambar Balaji,Kanth, Boddu Shashi,Satyakumar, Avula,Kamble,Das, Biswanath
, p. 317 - 323 (2013/07/26)
The stereoselective synthesis of the unsaturated lactone intermediates, (S) - and (R)-2-(6-oxo-3, 6-dihydro-2Hpyran-2-yl) acetaldehydes has been accomplished from propane 1,3 diol employing Maruoka asymmetric allylation and ring closing metathesis reaction. The intermediates were converted into two natural dihydropyranones, 6 (R)-4-oxopent-2-enyl 5,6-dihydro-2H-pyran-2-one and (R)- rugulactone and their enantiomers through Wittig olefination.
An improved stereoselective total synthesis of (R)-rugulactone
Goswami, Abhishek,Saikia, Partha Pratim,Saikia, Bishwajit,Chaturvedi, Devdutt,Barua, Nabin C.
, p. 5133 - 5135 (2011/10/19)
A novel route for the stereoselective total synthesis of (R)-rugulactone 1 has been developed, starting from substituted epoxide 4 and 3- phenylpropionaldehyde 5 employing Julia-Kocienski olefination as a key step to construct E-configured α,β-unsaturated keto-group. The overall yield of the synthesized rugulactone is 19.94% and is better than the reported methods.
