1426243-45-9Relevant academic research and scientific papers
A 19F NMR label to substitute polar amino acids in peptides: A CF3-substituted analogue of serine and threonine
Tkachenko, Anton N.,Mykhailiuk, Pavel K.,Afonin, Sergii,Radchenko, Dmytro S.,Kubyshkin, Vladimir S.,Ulrich, Anne S.,Komarov, Igor V.
, p. 1486 - 1489 (2013)
Rigid & polar: The cyclobutane scaffold was used to design the first polar nonperturbing rigid CF3-substituted amino acid (left in picture) suitable for replacing the serine/threonine residues in peptides. This amino acid imitates the geometry, structure, and function of serine and threonine, but in contrast to those, it can be used in structural studies of membrane-active Ser/Thr-containing peptides by solid-state 19F NMR spectroscopy. Copyright
Trans-1-hydroxy-1-(trifluoromethyl)-3-aminocyclobutane hydrochloride intermediate, and preparation method and applications thereof
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Paragraph 0061-0064; 0102-0105; 0115-0118, (2019/08/12)
The invention discloses a key intermediate used for synthesis of trans-1-hydroxy-1-(trifluoromethyl)-3-aminocyclobutane hydrochloride intermediate for the first time, and a preparation method and applications thereof. The preparation method comprises foll
